Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population

Table 5

Association of genotypes with histopathological and immunohistochemical characteristics.

Variables	rs3803304		rs2494732
	CC	CG+GG	CC	CT+TT
Affected breast
Right	28 (30.8)	24 (26.4)	24 (26.4)	28 (30.8)
Left	26 (28.6)	13 (14.3)	17 (18.7)	22 (24.2)
OR (95% CI)	0.6 (0.2-1.4)		1.1 (0.5-3.6)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
Tumor stage
T1-T2	43 (48.9)	27 (30.7)	32 (36.4)	38 (43.2)
T3-T4	8 (9.1)	10 (11.4)	7 (7.9)	11 (12.5)
OR (95% CI)	1.9 (0.7-5.7)		1.3 (0.5-3.8)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
LN status
+	29 (31.9)	18 (19.8)	22 (24.1)	25 (27.5)
-	25 (27.5)	19 (20.9)	19 (20.9)	25 (27.5)
OR (95% CI)	1.2 (0.5-2.8)		1.2 (0.5-2.6)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
ER status
+	33 (36.3)	26 (28.6)	26 (28.6)	33 (36.3)
-	21 (23.1)	11 (12.1)	15 (16.5)	17 (18.7)
OR (95% CI)	0.7 (0.3-1.6)		0.9 (0.4-2.1)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
PR status
+	31 (34.1)	24 (26.4)	25 (27.5)	30 (33.0)
-	23 (25.3)	13 (14.3)	16 (17.6)	20 (22.0)
OR (95% CI)	0.7 (0.3-1.7)		1.0 (0.4-2.4)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
HER2 status
+	12 (13.2)	15 (16.5)	11 (8.8)	16 (20.9)
-	42 (46.2)	22 (24.2)	30 (25.3)	34 (45.1)
OR (95% CI)	0.4 (0.2-1.0)		0.8 (0.3-1.9)
P value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05
Surgical margins
+	33 (36.3)	28 (30.8)	25 (27.5)	36 (39.6)
-	21 (23.1)	9 (9.9)	16 (17.6)	14 (15.4)
OR (95% CI)	0.5 (0.1-1.3)		0.6 (0.3-1.5)
value	P > 0.05, Q > 0.05		P > 0.05, Q > 0.05

LN, lymph node; PR, progesterone receptor; ER, estrogen receptor; HER, human epidermal growth factor receptor.
Analyses of 88 individuals.