Peroxisome Proliferator-Activated Receptor- Prevents Cholesterol Gallstone Formation in C57bl Mice by Regulating Bile Acid Synthesis and Enterohepatic Circulation

Figure 3

Pioglitazone altered gallbladder bile profiles, leading to a decreased biliary cholesterol saturation index (CSI) in mice fed on LGD. (a) Biliary cholesterol concentration, (b) biliary bile acid (BA) concentration, (c) biliary phospholipid concentration, and (d) biliary CSIs calculated according to parameters in panels (a–c). Results are presented as mean ± standard error of the mean (SEM) (n=7/group). P<0.05, P<0.01, and P>0.05.

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