Dynamics and Thermodynamics of Transthyretin Association from Molecular Dynamics Simulations

Figure 1

Cartoon view of tetrameric (a) and dimeric ((b) and (c)) assemblies of WT-TTR. Residues involved in the mutation (F87 (orange), L110 (cyan), and S117 (purple-blue)) are shown explicitly (stick representation) as well as the label of different -stranded regions schematised in Figure 2, PDB id 1F41 [9].

(a)

(b)

(c)