Development of a Novel Diagnostic Biomarker Set for Rheumatoid Arthritis Using a Proteomics Approach

Figure 5

Differentiation of disease activity during drug treatment. (a–f) The 6 selected candidate biomarkers were measured in patients in remission and in patients in nonremission. (g-i) ROC curve analysis for rheumatoid factor, anti-CCP, and 3-biomarker set, including SAA4, gelsolin, and VDBP to evaluate the ability of the biomarkers to distinguish patients with RA from healthy controls. Plots indicate individual protein abundances in patients. Data are shown as mean ± SEM. p < 0.05 (independent t-test).