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BioMed Research International
Volume 2018, Article ID 7518026, 5 pages
Clinical Study

Oxytocin Administration in High-Intensity Focused Ultrasound Treatment of Myomata

1Specialist Hospital Pro-Familia, Rzeszow, Poland
2Chair of Electroradiology, Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Poland
3Department of Obstetrics, Gynecology and Oncology, The Gabriel Narutowicz Hospital, Krakow, Poland
4Department of Obstetrics and Perinatology, Faculty of Health Sciences, Medical University of Warsaw, Zwirki i Wigury Str. 63a, 02-091 Warsaw, Poland

Correspondence should be addressed to Piotr Wegrzyn;

Received 28 July 2017; Revised 7 January 2018; Accepted 14 May 2018; Published 2 July 2018

Academic Editor: Sven Becker

Copyright © 2018 Tomasz Lozinski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. Methods. 156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy. Before and after the procedure we performed MR and measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR). The follow-up was up to 15 months to assess efficacy of treatment and relief of symptoms. Results. Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). The remaining parameters did not show significant difference between both groups. Conclusion. Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. This study’ clinical registration number is DRKS00014794.