Bioinformatics Analysis of the Molecular Mechanism of Aging on Fracture Healing

Table 1

GO terms enriched by DEGs at three time-points following bone fracture.

Category	Term	Description	P-value
Old vs young (day 1)
	GO:0030199	collagen fibril organization	8.90E-09
	GO:0001501	skeletal system development	3.32E-06
	GO:0009888	tissue development	5.61E-06
	GO:0051241	negative regulation of multicellular organismal process	6.96E-06
	GO:0010721	negative regulation of cell development	2.37E-05
	GO:0009887	animal organ morphogenesis	2.37E-05
	GO:0060343	trabecula formation	1.04E-04
	GO:0060346	bone trabecula formation	1.08E-04
	GO:0071229	cellular response to acid chemical	1.36E-04
	GO:0001101	response to acid chemical	1.61E-04
Old vs young (day 3)
	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	5.58E-07
	GO:0071805	potassium ion transmembrane transport	7.41E-07
	GO:0071804	cellular potassium ion transport	7.41E-07
	GO:0055085	transmembrane transport	1.83E-05
	GO:0015672	monovalent inorganic cation transport	1.29E-04
	GO:1990118	sodium ion import into cell	1.77E-04
	GO:0010876	lipid localization	1.91E-04
	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis	1.94E-04
	GO:0034113	heterotypic cell-cell adhesion	2.40E-04
	GO:0034220	ion transmembrane transport	2.59E-04
Old vs young (day 5)
	GO:0010951	negative regulation of endopeptidase activity	1.61E-08
	GO:0098916	anterograde trans-synaptic signaling	5.80E-07
	GO:0099537	trans-synaptic signaling	5.98E-07
	GO:0099536	synaptic signaling	7.67E-07
	GO:0006950	response to stress	1.15E-06
	GO:0051346	negative regulation of hydrolase activity	2.41E-06
	GO:0007270	neuron-neuron synaptic transmission	1.00E-05
	GO:0006955	immune response	1.81E-05
	GO:0006508	proteolysis	2.27E-05
	GO:0007268	chemical synaptic transmission	4.16E-05

GO, gene ontology; DEGs, differentially expressed genes.