Lysophosphatidic Acid Analogue rather than Lysophosphatidic Acid Promoted the Bone Formation In Vivo

Figure 5

LPA analogue rather than LPA promoted the bone formation in vivo. (a) Micro-CT 3D reconstruction images of LPA and LPA analogue-treated group at different time points. (b) Changes of osseous gaps in testing animals at the end of 2, 5, and 10 weeks. (c) Results from Micro-CT of the ROI for bone volume over total volume (BV/TV) at different time points. (d) Mean density of bone volume of LPA and LPA analogue group at different time points. (e) The compressive strength of femur from LPA analogue group was greater than control and LPA group. (f) Three-point bending of femur from LPA analogue group was greater than control and LPA group. (g) H&E staining of LPA and LPA analogue group at 2, 5, and 10 weeks after operation (bar=500 μm).