BioMed Research International / 2018 / Article / Tab 2

Review Article

Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective

Table 2

Plant derivatives work as scaffolds for application in tissue engineering.

ReferencesPlant-derived substancesDelivery systemStudy designCell line/Animal modelConclusion

[15]Agaroseagarose gel mixed with adenovirus-mediated human BMP-2 gene transduced bone marrow stromal cellsin vivoathymic miceThe agarose-gene-transduced BMSC gel was found to contain much more hyaline cartilage than the alginate and collagen gel.

[16]Aloe vera gel extractsacemannan spongesin vivomongrelsAcemannan could be a candidate osteoinductive biomaterial for periodontal tissue regeneration.

[17]Soybeansoybean granulesin vivoNew Zealand rabbitsSoybean-based biomaterial may become a potent active osteoinductive material for periodontal regeneration.

[18]Cissus quadrangularis (CQ) extracts with alginate (Alg)alginate/O -carboxymethyl chitosan/ Cissus quadrangularis scaffoldin vitrohMSCsThe hybrid scaffold owned a substantially osteoinductive capacity, which could serve as a potential candidate for bone tissue engineering therapeutics.

[19]Genipingenipin-crosslinked chitosan hydrogelsin vitroosteosarcoma (MG-63) cells, hMSCsGenipin cross-linked chitosan scaffolds are suitable systems for bone tissue engineering. Different genipin concentrations effectively change the degradation profile, the structural and mechanical properties of the scaffolds.

[20]Genipinelectrospun from chitosan crosslinked with genipinin vitro/in vivomurine mesenchymal stem cells/CD1 female miceThe presence of HA in the CTS-GP scaffold significantly enhanced their osseointegrative capacity, making it unique biomaterial for repair of bone defect.

[21]Alginatealginate/nano bioactive glass ceramic compositein vitroMG-63 cells, human periodontal ligament fibroblastsThe results suggest that these biocompatible composite scaffolds have possible relevance for periodontal tissue regeneration.

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