Susceptibility of Diabetic Mice to Noise Trauma

Figure 1

Schematic time course of the experiments. Auditory brainstem response (ABR) thresholds were measured prior to; immediately after; and at 1 day, 1 week, and 2 weeks after noise exposure. Reactive oxygen species and inflammatory responses were evaluated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) prior to; immediately after; and at 1 day, 3 days, and 1 week after noise exposure. The numbers of hair cells and inner hair cell synapses were assessed at 2 weeks after noise exposure. Five diabetic and 5 wild-type animals were used for each time point.