Simvastatin Impairs the Inflammatory and Repair Phases of the Postinjury Skeletal Muscle Regeneration

Figure 1

Scheme of experimental study design. The animals were divided into the nontreated (control) and SIM-treated groups. The oral administration of SIM (40 mg/day/animal) was started 14 days prior to muscle injury and was continued after injury. On the 15th day of the experiment (day 0), muscle injury was induced by BPVC. The animals were sacrificed at various days after the injury was induced (three gilts/group/experimental day), and muscle samples were collected for evaluation.