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BioMed Research International
Volume 2018, Article ID 7619092, 9 pages
Review Article

Functional Assessment of Intermediate Vascular Disease

1Department of Internal Medicine, Cardiology Clinic, Medical University Sofia, Sofia, Bulgaria
2“Angel Kanchev” University of Ruse, Ruse, Bulgaria

Correspondence should be addressed to Teodora Yaneva-Sirakova; moc.liamg@avenay.arodoet

Received 7 June 2017; Revised 12 September 2017; Accepted 28 January 2018; Published 15 April 2018

Academic Editor: Gelin Xu

Copyright © 2018 Teodora Yaneva-Sirakova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Interventional treatment in various vascular beds has advanced tremendously. However, there are several problems to be considered. We searched the literature and tried to analyze major parts of it. One is safety and applicability of coronary proven methods in other vascular beds. An unresolved problem is the functional assessment of intermediate lesions, as far as various target organs have quite different circulation from the coronary one and the functional tests should be modified in order to be applicable and meaningful. In the majority of the acute vascular syndromes, the culprit lesion is of intermediate size on visual assessment. On the other hand, a procedurally successfully managed high-degree stenosis is not always followed by clinical and prognostic benefit. In vascular beds, where collateral network naturally exists, the readings from the functional assessment are complicated and thus the decision for interventional treatment is even more difficult. Here come into help the functional assessment and imaging with IVUS, OCT, high-resolution MRI, and contrast enhanced CT or SPECT. The focus of the current review is on the functional assessment of intermediate stenosis in other vascular beds, unlike the coronary arteries.