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Title | First author | Journal | Impact factor | Year | Citations | Citation frequency per year | Main Conclusion |
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis | Gupta, Rajnish | Nature | 40.14 | 2010 | 1821 | 227.62 | The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in is a powerful predictor of eventual metastasis and death. |
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Long non-coding RNAs: insights into functions | Mercer, Tim | Nature Reviews Genetics | 40.28 | 2009 | 1565 | 173.89 | In this review, they focus on the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome, their roles in gene regulation and their medical implications. |
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Evolution and Functions of Long Noncoding RNAs | Ponting, Chris | Cell | 30.41 | 2009 | 1286 | 142.89 | They reviewed the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease. |
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes | Tsai, Miao-Chih | Science | 37.20 | 2010 | 1230 | 153.75 | LincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes. |
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The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression | Derrien, Thomas | Genome Research | 11.92 | 2012 | 1208 | 201.33 | They presented and analyzed the human lncRNA annotation, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts. |
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Genome Regulation by Long Noncoding RNAs | Rinn, John | Annual Review of Biochemistry | 19.94 | 2012 | 1007 | 167.83 | LncRNAs can function as modular scaffolds to specify higher-order organization in RNP complexes and in chromatin states. |
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Molecular Mechanisms of Long Noncoding RNAs | Wang, Kevin | Molecular Cell | 14.71 | 2011 | 912 | 130.29 | They discussed the emerging archetypes of molecular functions that lncRNAs execute-as signals, decoys, guides, and scaffolds. |
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lincRNAs act in the circuitry controlling pluripotency and differentiation | Guttman, Mitchell | Nature | 40.14 | 2011 | 818 | 116.86 | They performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem (ES) cells, and found that knockdown of lincRNAs has major consequences on gene expression patterns. |
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Long Noncoding RNAs with Enhancer-like Function in Human Cells | Orom, Ulf Andersson | Cell | 30.41 | 2010 | 790 | 98.75 | Depletion of a number of ncRNAs led to decreased expression of their neighboring protein-coding genes, including the master regulator of hematopoiesis, SCL (also called TAL1), Snai1 and Snai2. |
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Long noncoding RNAs: functional surprises from the RNA world | Wilusz, Jeremy | Genes & Development | 9.41 | 2009 | 749 | 83.22 | LncRNAs can function via numerous paradigms and are key regulatory molecules in the cell. |
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