Bibliometric Analysis of Global Scientific Research on lncRNA: A Swiftly Expanding Trend

Table 3

Top 10 lncRNA research with the most citation frequency.

Title	First author	Journal	Impact factor	Year	Citations	Citation frequency per year	Main Conclusion
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis	Gupta, Rajnish	Nature	40.14	2010	1821	227.62	The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in is a powerful predictor of eventual metastasis and death.
Long non-coding RNAs: insights into functions	Mercer, Tim	Nature Reviews Genetics	40.28	2009	1565	173.89	In this review, they focus on the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome, their roles in gene regulation and their medical implications.
Evolution and Functions of Long Noncoding RNAs	Ponting, Chris	Cell	30.41	2009	1286	142.89	They reviewed the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes	Tsai, Miao-Chih	Science	37.20	2010	1230	153.75	LincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression	Derrien, Thomas	Genome Research	11.92	2012	1208	201.33	They presented and analyzed the human lncRNA annotation, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts.
Genome Regulation by Long Noncoding RNAs	Rinn, John	Annual Review of Biochemistry	19.94	2012	1007	167.83	LncRNAs can function as modular scaffolds to specify higher-order organization in RNP complexes and in chromatin states.
Molecular Mechanisms of Long Noncoding RNAs	Wang, Kevin	Molecular Cell	14.71	2011	912	130.29	They discussed the emerging archetypes of molecular functions that lncRNAs execute-as signals, decoys, guides, and scaffolds.
lincRNAs act in the circuitry controlling pluripotency and differentiation	Guttman, Mitchell	Nature	40.14	2011	818	116.86	They performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem (ES) cells, and found that knockdown of lincRNAs has major consequences on gene expression patterns.
Long Noncoding RNAs with Enhancer-like Function in Human Cells	Orom, Ulf Andersson	Cell	30.41	2010	790	98.75	Depletion of a number of ncRNAs led to decreased expression of their neighboring protein-coding genes, including the master regulator of hematopoiesis, SCL (also called TAL1), Snai1 and Snai2.
Long noncoding RNAs: functional surprises from the RNA world	Wilusz, Jeremy	Genes & Development	9.41	2009	749	83.22	LncRNAs can function via numerous paradigms and are key regulatory molecules in the cell.