Table 3: Top 10 lncRNA research with the most citation frequency.

TitleFirst authorJournalImpact factorYearCitationsCitation frequency per yearMain Conclusion

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasisGupta, RajnishNature40.1420101821227.62The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in is a powerful predictor of eventual metastasis and death.

Long non-coding RNAs: insights into functionsMercer, TimNature Reviews Genetics40.2820091565173.89In this review, they focus on the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome, their roles in gene regulation and their medical implications.

Evolution and Functions of Long Noncoding RNAsPonting, ChrisCell30.4120091286142.89They reviewed the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.

Long Noncoding RNA as Modular Scaffold of Histone Modification ComplexesTsai, Miao-ChihScience37.2020101230153.75LincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expressionDerrien, ThomasGenome Research11.9220121208201.33They presented and analyzed the human lncRNA annotation, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts.

Genome Regulation by Long Noncoding RNAsRinn, JohnAnnual Review of Biochemistry19.9420121007167.83LncRNAs can function as modular scaffolds to specify higher-order organization in RNP complexes and in chromatin states.

Molecular Mechanisms of Long Noncoding RNAsWang, KevinMolecular Cell14.712011912130.29They discussed the emerging archetypes of molecular functions that lncRNAs execute-as signals, decoys, guides, and scaffolds.

lincRNAs act in the circuitry controlling pluripotency and differentiationGuttman, MitchellNature40.142011818116.86They performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem (ES) cells, and found that knockdown of lincRNAs has major consequences on gene expression patterns.

Long Noncoding RNAs with Enhancer-like Function in Human CellsOrom, Ulf AnderssonCell30.41201079098.75Depletion of a number of ncRNAs led to decreased expression of their neighboring protein-coding genes, including the master regulator of hematopoiesis, SCL (also called TAL1), Snai1 and Snai2.

Long noncoding RNAs: functional surprises from the RNA worldWilusz, JeremyGenes & Development9.41200974983.22LncRNAs can function via numerous paradigms and are key regulatory molecules in the cell.