RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy

Figure 2

Toll-like receptor signaling pathways. IRFs: interferon regulatory factors, NF-κB: nuclear factor κB, IRAK: IL-1 receptor-associated kinases; MAL: MyD88-adaptor-like; MyD88: Myeloid differentiation protein 88; TLR: toll-like receptor; TRAF: tumour necrosis factor receptor-associated factor 6; TRAM: TRIF-related adaptor molecule; TRIF: TIR domain-containing adaptor inducing interferon-β. IκBα: inhibitory protein kappa-B and IKK: inhibitor of nuclear factor kappa-B kinase.