Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study

Table 3

Comparison of genotype frequencies in each SNP locus of the UGT1A1, OAP1B1, and HO-1 genes between the case and control groups.

Gene	SNP locus		Frequency in the case group()	Frequency in the control group ()		χ^2	P	OR(95%CI)
UGT1A1	(TA)n repeat rs8175347	TA6/TA6	84.3	80	0.194	1.665	0.197	1
		TA6/TA7	15.7	20				1.339(0.859–2.088)
		TA7/TA7	0	0				-
	rs4148323	GG	51	65.2	0.957	16.95	0	1
		GA	38.1	31.6				1.504(1.069–2.221)
		AA	10.8	3.2				4.326(1.927–9.712)
OAP1B1	rs2306283	GG	55.6	58.4	0.533	2.863	0.239	1
		GA	39.2	33.6				1.224(0.853–1.757)
		AA	5.2	8				0.689(0.340–1.395)
	rs4149056	TT	80.4	84.4	0.002
		TC	11.9	10.4
		CC	7.7	5.2
HO-1	(GT)n repeat rs1805173	LL	22.4	34.4	0.091	13.84	0.017	1
		LM	14.3	14.4				1.530 (0.881–2.659)
		LS	29.4	24.8				1.821(1.148–2.886)
		MM	6.3	7.2				1.344(0.648–2.786)
		MS	17.5	14.4				1.866(1.091–3.193)
		SS	10.1	4.8				3.247(1.539–6.851)