Research Article
Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study
Table 3
Comparison of genotype frequencies in each SNP locus of the UGT1A1, OAP1B1, and HO-1 genes between the case and control groups.
| Gene | SNP locus | Frequency in the case group() | Frequency in the control group () | | χ2 | P | OR(95%CI) |
| UGT1A1 | (TA)n repeat rs8175347 | TA6/TA6 | 84.3 | 80 | 0.194 | 1.665 | 0.197 | 1 | TA6/TA7 | 15.7 | 20 | 1.339(0.859–2.088) | TA7/TA7 | 0 | 0 | - | rs4148323 | GG | 51 | 65.2 | 0.957 | 16.95 | 0 | 1 | GA | 38.1 | 31.6 | 1.504(1.069–2.221) | AA | 10.8 | 3.2 | 4.326(1.927–9.712) | OAP1B1 | rs2306283 | GG | 55.6 | 58.4 | 0.533 | 2.863 | 0.239 | 1 | GA | 39.2 | 33.6 | 1.224(0.853–1.757) | AA | 5.2 | 8 | 0.689(0.340–1.395) | rs4149056 | TT | 80.4 | 84.4 | 0.002 | | | | TC | 11.9 | 10.4 | | CC | 7.7 | 5.2 | | HO-1 | (GT)n repeat rs1805173 | LL | 22.4 | 34.4 | 0.091 | 13.84 | 0.017 | 1 | LM | 14.3 | 14.4 | 1.530 (0.881–2.659) | LS | 29.4 | 24.8 | 1.821(1.148–2.886) | MM | 6.3 | 7.2 | 1.344(0.648–2.786) | MS | 17.5 | 14.4 | 1.866(1.091–3.193) | SS | 10.1 | 4.8 | 3.247(1.539–6.851) |
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