Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study
Table 5
Logistic regression analysis of genetic risk factors for neonatal hyperbilirubinemia.
Risk factor
SE
Waldχ2
P
OR(95%CI)
SNP rs4148323 in the UGT1A1 gene
AA
1.459
0.426
11.76
0.001
4.303 (1.869–9.911)
GA
0.429
0.194
4.877
0.027
1.536(1.049–2.248)
G6PD deficiency
1.355
0.522
6.733
0.009
3.877(1.393–10.79)
ABO incompatibility
0.971
0.267
12.22
0
2.64(1.564–4.455)
(GT)n repeat rs1805173 in the HO-1 gene#
LM
0.437
0.292
2.233
0.135
1.548(0.873–2.744)
LS
0.46
0.246
3.504
0.061
1.585(0.979–2.566)
MM
0.449
0.382
1.379
0.24
1.567(0.74–3.316)
MS
0.443
0.289
2.357
0.125
1.557(0.885–2.742)
SS
1.116
0.391
8.125
0.004
3.051(1.417–6.57)
The wild-type GG genotype served as a reference for SNP rs4148323 in the UGT1A1 gene; # the wild-type GG genotype served as a reference for (GT)n repeat variant rs1805173 in the HO-1 gene.
