Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus

<div>NaSal administration impaired the expression of delta-FosB during spatial memory retrieval. (a) Representative immunohistochemical staining of delta-FosB-positive cells in the hippocampal CA1 region from NaSal-treated and control rats. (b) Contrasting expression of delta-FosB during the retrieval of the spatial memory in NaSal-treated and control rats. Independent-samples <svg height="8.02022pt" id="M55" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z" id="g113-117"></path></g></svg>-tests revealed that NaSal treatment showed a significant decrease on the day of the probe test in the rats treated for 7 [<svg height="8.02022pt" id="M56" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 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BioMed Research International

fig4

Figure 4

Figure 4: Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus 