A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Table 1

Association between hyperoxemia and clinically relevant outcomes after myocardial infarction and cardiac arrest.

Reference	Study design	Sample size	Hyperoxemia definition	Condition	Location	Conclusion
[20], Ranchordet al.	RCT	136	6 L O2/min	STEMI	-	High-O2 therapy had no effect on mortality or infarct size
[21], Spindelboeck et al.	Retrospective cohort	1015	PaO2 40.0 kPa	Cardiac arrest	Pre-hospital	Higher hospital admission rates when during CPR
[22], Vaahersalo et al.	Prospective cohort	409	PaO2 40.0 kPa	Cardiac arrest	ICU	No association with different 12 month outcome
[23], Ihle et al.	Retrospective cohort	584	PaO2 40.0 kPa	Cardiac arrest	ICU	No association with in-hospital mortality
[24], Helmerhorst et al.	Retrospective cohort	5258	PaO2 > 39.9 kPa	Cardiac arrest	ICU	Hyperoxia not associated with higher mortality rates
[25], Bellomo et al.	Retrospective cohort	12,108	PaO2 40.0 kPa	Cardiac arrest	ICU	No association with mortality
[26], Chirst et al.	Retrospective cohort	134	-	Cardiac arrest	-	Hyperoxia in the first 60 minutes after return of circulation is associated with better survival rates
[27], Lee et al.	Retrospective cohort	213	-	Cardiac arrest	-	Hypocarbia associated with in-hospital mortality. Hypoxemia and hyperoxemia associated with poor neurological outcome.
[28], Kilgannon et al.	Retrospective cohort	6,326	PaO2 40.0 kPa	Cardiac arrest	ICU	Higher mortality rates, even when compared to hypoxemia
[29], Elmer et al.	Retrospective analysis of prospective registry	184	Severe: PaO2 40.0 kPa; Moderate/ probable: PaO2 13.5–39.9 kPa	Cardiac arrest	ICU	Severe associated with higher in-hospital mortality. Moderate/probable was not but was associated with improved organ function after 24 hours.
[30], Kilgannon et al.	Retrospective cohort	4,459	-	Cardiac arrest	ICU	Dose-dependent association with in-hospital mortality
[31], Janz et al.	Post-hoc analysis of prospective cohort	170	-	Cardiac arrest	Cardiovascular care unit	Higher in-hospital mortality and poor neurological status on hospital discharge in survivors
[32], Young et al.	RCT	18	-	Cardiac arrest	Prehospital	Study terminated early, because pre-hospital oxygen titration was not feasible.