BioMed Research International / 2018 / Article / Tab 1

Review Article

A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Table 1

Association between hyperoxemia and clinically relevant outcomes after myocardial infarction and cardiac arrest.

Reference Study designSample sizeHyperoxemia definitionConditionLocationConclusion

[20], Ranchordet al.RCT1366 L O2/minSTEMI-High-O2 therapy had no effect on mortality or infarct size

[21], Spindelboeck et al.Retrospective cohort1015PaO2 40.0 kPaCardiac arrestPre-hospitalHigher hospital admission rates when during CPR

[22], Vaahersalo et al.Prospective cohort409PaO2 40.0 kPaCardiac arrestICUNo association with different 12 month outcome

[23], Ihle et al.Retrospective cohort584PaO2 40.0 kPaCardiac arrestICUNo association with in-hospital mortality

[24], Helmerhorst et al.Retrospective cohort5258PaO2 > 39.9 kPaCardiac arrestICUHyperoxia not associated with higher mortality rates

[25], Bellomo et al.Retrospective cohort12,108PaO2 40.0 kPaCardiac arrestICUNo association with mortality

[26], Chirst et al.Retrospective cohort134-Cardiac arrest-Hyperoxia in the first 60 minutes after return of circulation is associated with better survival rates

[27], Lee et al.Retrospective cohort213-Cardiac arrest-Hypocarbia associated with in-hospital mortality. Hypoxemia and hyperoxemia associated with poor neurological outcome.

[28], Kilgannon et al.Retrospective cohort6,326PaO2 40.0 kPaCardiac arrestICUHigher mortality rates, even when compared to hypoxemia

[29], Elmer et al.Retrospective analysis of prospective registry184Severe:
PaO2 40.0 kPa
Moderate/ probable:
PaO2 13.5–39.9 kPa
Cardiac arrestICUSevere associated with higher in-hospital mortality. Moderate/probable was not but was associated with improved organ function after 24 hours.

[30], Kilgannon et al.Retrospective cohort4,459-Cardiac arrestICUDose-dependent association with in-hospital mortality

[31], Janz et al.Post-hoc analysis of prospective cohort170-Cardiac arrestCardiovascular care unitHigher in-hospital mortality and poor neurological status on hospital discharge in survivors

[32], Young et al.RCT18-Cardiac arrestPrehospitalStudy terminated early, because pre-hospital oxygen titration was not feasible.

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