BioMed Research International / 2018 / Article / Tab 2

Review Article

A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Table 2

Association between hyperoxemia and clinically relevant outcomes after stroke and traumatic brain injury.

Reference Study designSample sizeHyperoxemia definitionConditionLocationConclusion

[33], Young et al.Retrospective cohort2,643-Ischaemic strokeICUNo association with mortality.

[34], Rincon et al.Retrospective cohort2,894PaO2 40.0 kPaIschaemic stroke, subarachnoid or intracerebral hemorrhageICUAssociated with higher in-hospital mortality, also when compared to hypoxemia.

[35], Lång et al.Retrospective cohort432-Subarachnoidal hemorrhageICUUnfavorable outcome associated with higher PaO2, but higher PaO2 levels after multivariate analysis not associated with unfavorable outcome or mortality

[36], Singhal et al.Randomized pilot study, partially blinded16O2 45 L/min, 8 hoursIschaemic stroke-Transient improvement of clinical deficits and MRI abnormalities after 24 hours

[37], Padma et al.Randomized pilot study, partially blinded40O2 10 L/min, 12 hoursIschaemic stroke-No improvement in functional or neurological outcome after 3 months

[38], Nortje et al.Prospective cohort11FiO2 35–50%TBI-Increases brain tissue oxygenation.

[39], Tisdall et al.Prospective cohort8FiO2 100%TBINeurological ICUIncreases cerebral aerobic metabolism.

[40], Vilalta et al.Prospective cohort30FiO2 100%TBIICUImproves brain redox state in patients with initially elevated brain lactate levels

[41], Diringer et al.Prospective cohort5FiO2 100%TBINeurosurgical ICUNo improvement on brain metabolism.

[42], Puccio et al.Prospective cohort11FiO2 100%TBINeurotrauma ICUBrief periods do not produce oxidative stress and/or change antioxidant reserves in cerebrospinal fluid.

[43], Davis et al.Retrospective cohort3,420PaO2 64.9 kPaTBI-Independently associated with increased mortality and decrease in good outcomes.

[44], Rincon et al.Retrospective cohort1,212PaO2 40.0 kPaTBIICUIndependently associated with higher in-hospital mortality.

[45], Asher et al.Retrospective cohort193PaO2 64.8 kPaTBI-Decrease in survival

[46], Raj et al.Retrospective cohort1,116PaO2 13.3 kPaTBIICUNo effect on 6 month mortality

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