A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Table 3

Association between hyperoxemia and clinically relevant outcomes in sepsis.

Reference	Study design	Sample size	Hyperoxemia definition	Condition	Location	Conclusion
[19], Stolmeijer et al.	Prospective cohort	83	PaO2 > 13.5 kPa	Sepsis	ED	More than 64% of patients were hyperoxemic with 10 L O2/min. No association with mortality.
[47], Rossi et al.	Prospective cohort	14	FiO2 100%	Sepsis	ICU	Decreases oxygen delivery in upper limbs.
[48], Pope et al.	Retrospective cohort	619	Central venous saturation (ScvO2) 90–100%	Sepsis	ED	Associated with increased mortality.
[49], Dahl et al.	Retrospective cohort	1,770	PaO2 16.0 kPa	Sepsis	ICU	No effect on mortality, but hypoxemia and FiO2 60% increased mortality.