Review Article

Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System

Table 2

Synthetic materials scaffold applied in CNS.

Material DescriptionApplication in SCIApplication in brain injury

FGLmxHydrogelFunction recovery, axonal regeneration, stem cell therapy [204]

Poly-ε-caprolactoneHydrogelCell survival, delivering neurotrophic factor [205]
Biodegradable scaffoldCell survival, stem cell therapy, functional recovery [206, 207]Axonal regeneration, cell survival, functional recovery, stem cell therapy [161, 164]

Poly(ethylene glycol)HydrogelAxonal regeneration, functional improvements, anti-inflammation, cell survival [208, 209]Axonal regeneration, anti-inflammation, cell survival, delivering neurotrophic factor [210, 211]
Biodegradable scaffoldFunction recovery, axonal regeneration, anti-inflammation [212]

Poly(hydroxyethyl methacrylate)HydrogelNerve tissue regeneration and functional recovery, stem cell therapy [121, 213]Cell survival, axonal regeneration [214]

Poly(hydroxypropyl methacrylate)HydrogelFunction recovery, axonal regeneration, anti-inflammation, delivering neurotrophic factor, stem cell therapy [76, 215]Axonal regeneration, anti-inflammation [216]

Poly(lactide-co-glycolic acid)Biodegradable scaffoldAxonal regeneration, tissue repair, delivering neurotrophic factor, stem cell therapy [145, 217219]Axonal regeneration, tissue repair [220]

PolyurethaneHydrogelCell survival, axonal regeneration, functional recovery, stem cell therapy [221]Cell survival, axonal regeneration, functional recovery, stem cell therapy [221]
Biodegradable scaffoldCell survival, axonal regeneration, functional recovery, stem cell therapy [221]

Hydroxy ethyl methacrylateHydrogelStem cell therapy and axons repair [222]

PuraMatrixHydrogelFunctional recovery, spinal repair, and neuronal regeneration [223, 224]Stem cell therapy [225]

Imidazole-poly(organophosphazenes)HydrogelFunction recovery, axonal regeneration, anti-inflammation [140]