In Vitro Antibacterial Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate Derived from Allium spp. against Gram-Negative and Gram-Positive Multidrug-Resistant Bacteria Isolated from Human Samples

Table 2

Activity in vitro of PTS, PTSO, and others antibacterial agents against gram-positive organisms.

Organisms (number of isolates)	MIC50	MIC90	MBC50	MBC90	of resistant isolates
	(in mg/L)	(in mg/L)	(in mg/L)	(in mg/L)
Staphylococcus aureus methicillin-resistant (n=112)
Gentamicin	4	256	16	>256	48.2
Tobramycin	64	>256	>256	>256	79.5
Erythromycin	>64	>64	>64	>64	69.6
Clindamycin	>64	>64	>64	>64	49.1
Levofloxacin	8	32	32	>64	89.3
Linezolid	2	4	4	8	0.0
Vancomycin	0.5	1	1	4	0.0
Teicoplanin	0.25	1	0.5	4	0.0
Daptomycin	0.25	0.5	0.5	2	0.0
Rifampicin	≤0.03	0.5	0.125	1	3.6
Trimethoprim/sulfamethoxazole	≤0.06	0.5	0.5	2	3.6
PTS	64	128	512	1024	-
PTSO	8	8	32	64	-
Enterococcus faecalis (n=54)
Ampicillin	1	2	2	8	0.0
Levofloxacin	32	64	>64	>64	100
Linezolid	2	2	4	8	0.0
Vancomycin	0.5	1	2	4	0.0
Teicoplanin	≤0.03	0.125	0.25	1	0.0
Daptomycin	2	4	4	8	0.0
PTS	128	128	2048	4096	-
PTSO	4	8	8	16	-
Streptococcus agalactiae (n=101)
Ampicillin	0.06	0.125	0.125	0.5	0.0
Erythromycin	>64	>64	>64	>64	94.1
Clindamycin	>64	>64	>64	>64	85.1
Levofloxacin	0.5	1	2	8	6.9
Linezolid	1	2	2	4	0.0
Vancomycin	1	1	2	4	0.0
Daptomycin	0.125	0.5	0.5	2	0.0
PTS	64	128	512	2048	-
PTSO	4	8	8	16	-

MIC: minimum inhibitory concentration; MBC: minimum bactericidal concentration; % of resistant isolates: percentages of isolates intermediate or resistant according to the criteria published by the CLSI (2016).