Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis
Table 2
Biomechanical properties of femora in six groups.
Parameters
Blank
Negative control
High Dose
Medium Dose
Low Does
Positive Control
Extrinsic parameters
Fu(N)
217.79 ± 23.11
192.77 ± 21.83
212.09 ± 23.72
199.02 ± 16.80
197.88 ± 24.45
190.54 ± 14.36
Du (mm)
0.655 ± 0.084
0.856 ± 0.20
0.739 ± 0.099
0.687 ± 0.060
0.728 ± 0.096
0.665 ± 0.059
S(N/mm)
625.53 ± 99.31
508.87 ± 66.03
595.16 ± 80.14
603.27 ± 60.13
596.87 ± 69.75
562.52 ± 61.74
U (mJ)
89.57 ± 24.43
87.74 ± 25.17
98.66 ± 25.50
85.20 ± 14.87
89.83 ± 22.20
77.69 ± 10.00
Bone geometry
b (mm)
3.17 ± 0.17
3.13 ± 0.13
3.29 ± 0.21
3.21 ± 0.24
3.23 ± 0.16
3.24 ± 0.08
a (mm)
4.32 ± 0.16
4.07 ± 0.15
4.32 ± 0.36
4.13 ± 0.20
4.31 ± 0.23
4.21 ± 0.16
Ct.Th (mm)
0.89 ± 0.10
0.78 ± 0.07
0.87 ± 0.06
0.85 ± 0.02
0.85 ± 0.03
0.83 ± 0.05
CSMI (mm4)
6.47 ± 1.37
5.67 ± 0.80
7.20 ± 2.03
6.38 ± 1.62
6.72 ± 1.14
6.51 ± 0.48
Intrinsic parameters
(MPa)
203.09 ± 19.65
200.46 ± 17.76
186.41 ± 18.10
191.72 ± 15.21
179.82 ± 14.61
177.29 ± 15.73
(%)
5.56 ± 0. 95
7.14 ± 1.68
6.50 ± 1.03
5.88 ± 0.67
6.28 ± 0.92
5.64 ± 0.37
E (GPa)
6.96 ± 1.43
6.42 ± 1.31
6.01 ± 0.99
6.85 ± 1.10
6.32 ± 0.71
6.09 ± 0.67
(MJ/ m3)
6.97 ± 1.39
7.53 ± 1.79
7.51 ± 1.45
6.98 ± 1.04
7.04 ± 1.66
6.26 ± 0.81
Data are presented as mean ± standard deviation. Extrinsic parameters: Fu (ultimate force), Du (ultimate displacement), S (stiffness), and U (energy absorbed); bone geometry: b (anterior-posterior width), a (media-lateral width), Ct.Th (cortical thickness), and CSMI (cross-sectional moment of inertia); intrinsic parameters: (ultimate stress), (ultimate strain), E (elastic modulus), and (modulus of toughness). All the other five groups are compared with the negative control group (saline group), respectively. p < 0.05.
