Research Article
Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases
Table 1
Clinical data of all subjects.
| | | AITD | GD | HT | Control |
| | N | 780 | 488 | 292 | 789 | | Gender | | | | | | Male | 188 (24.10%) | 149 (30.53%) | 39 (13.36%) | 271 (34.35%) | | Female | 592 (75.90%) | 339 (69.47%) | 253 (86.64%) | 518 (65.65%) | | Age (mean ± s.d.) | | | | | | Family history (+) | 178 (22.82%) | 114 (23.36%) | 64 (21.92%) | - | | Titer of antibodies | | | | | | TPOAb (+) | 552 (70.77%) | 324 (66.39%) | 228 (78.08%) | - | | TGAb (+) | 628 (80.51%) | 386 (79.10%) | 242 (82.88%) | - | | Thyroid size | | | | - | | Normal size | 122 (15.64%) | 83 (17.008%) | 39 (13.36%) | - | | I degree | 135 (17.31%) | 88 (18.033%) | 47 (16.10%) | - | | II degree | 435 (55.77%) | 247 (50.615%) | 188 (64.38%) | - | | III degree | 88 (11.28%) | 70 (14.344%) | 18 (6.16%) | - |
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AITD, autoimmune thyroid disease; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; TPOAb, anti-thyroid peroxide antibody; TgAb, anti-thyroglobulin antibody.
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