Research Article
Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases
Table 3
Allele and genotype frequencies of IRGM SNPs in GD, HT patients, and controls.
| | SNP | Control (%) | GD (%) | | OR (95% CI) | HT (%) | | OR (95% CI) |
| | rs10065172 | | | | | | | | | CC | 275 (34.854) | 139 (28.48) | | | 99 (33.90) | | | | CT | 380 (48.162) | 252 (51.64) | 0.052 | - | 146 (50.00) | 0.859 | - | | TT | 134 (16.984) | 97 (19.88) | | | 47 (16.10) | | | | C | 930 (58.94) | 530 (54.30) | 0.022 | 1.208 (1.028-1.419) | 344 (58.90) | 0.990 | 1.001 (0.826-1.214) | | T | 648 (41.06) | 446 (45.70) | | | 240 (41.10) | | | | rs4958847 | | | | | | | | | AA | 293 (37.14) | 210 (43.00) | | | 115 (39.4) | | | | AG | 380 (48.16) | 220 (45.10) | 0.081 | - | 135 (46.2) | 0.792 | - | | GG | 116 (14.70) | 58 (11.90) | | | 42 (14.4) | | | | A | 966 (61.22) | 640 (65.57) | 0.027 | 0.829 (0.702-0.979) | 365 (62.50) | 0.586 | 0.947 (0.779-1.152) | | G | 612 (38.78) | 336 (34.43) | | | 219 (37.50) | | | | rs13361189 | | | | | | | | | TT | 275 (34.85) | 139 (28.50) | | | 100 (34.25) | | | | CT | 379 (48.04) | 253 (51.80) | 0.056 | - | 145 (49.66) | 0.874 | - | | CC | 135 (17.11) | 96 (19.70) | | | 47 (16.09) | 0.874 | - | | T | 929 (58.87) | 531 (54.41) | 0.027 | 1.200 (1.021-1.409) | 345 (59.08) | 0.932 | 0.992 (0.818-1.203) | | C | 649 (41.13) | 445 (45.59) | | | 239 (40.92) | | |
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GD, Graves’ disease; HT, Hashimoto’s thyroiditis; OR, odds ratio; 95% CI, 95% confidence intervals.
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