Research Article
Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases
Table 4
Association between SNPs of IRGM gene and AITD, GD, and HT by logistic regression analysis.
| Disease | Model | Unadjusted | Unadjusted OR (95% CI) | Adjusted | Adjusted OR (95% CI) |
| AITD | rs10065172 | | | | | | Allele model | 0.097 | 1.13 (0.98-1.30) | 0.145 | 1.11 (0.96-0.98) | | Dominant model | 0.067 | 1.22 (0.99-1.51) | 0.108 | 1.19 (0.96-1.48) | | rs4958847 | | | | | | Allele model | 0.063 | 0.87 (0.75-1.01) | 0.204 | 0.91 (0.78-1.05) | | Dominant model | 0.066 | 0.83 (0.68-1.01) | 0.169 | 0.86 (0.70-1.06) | | rs13361189 | | | | | | Allele model | 0.121 | 1.12 (0.97-1.29) | 0.179 | 1.10 (0.96-1.28) | | Dominant model | 0.076 | 1.21 (0.98-1.50) | 0.122 | 1.19 (0.96-1.47) |
| GD | rs10065172 | | | | | | Allele model | 0.021 | 1.21 (1.03-1.42) | 0.033 | 1.20 (1.02-1.41) | | Dominant model | 0.018 | 1.34 (1.05-1.72) | 0.024 | 1.33 (1.04-1.70) | | rs4958847 | | | | | | Allele model | 0.027 | 0.83 (0.70-0.98) | 0.084 | 0.86 (0.73-1.02) | | Dominant model | 0.036 | 0.78 (0.62-0.98) | 0.104 | 0.82 (0.65-1.04) | | rs13361189 | | | | | | Allele model | 0.026 | 1.20 (1.02-1.41) | 0.042 | 1.19 (1.01-1.40) | | Dominant model | 0.018 | 1.34 (1.05-1.72) | 0.026 | 1.33 (1.03-1.70) |
| HT | rs10065172 | | | | | | Allele model | 0.990 | 1.00 (0.83-1.22) | 0.763 | 1.03 (0.84-1.27) | | Dominant model | 0.771 | 1.04 (0.79-1.38) | 0.709 | 1.06 (0.79-1.42) | | rs4958847 | | | | | | Allele model | 0.585 | 0.95 (0.78-1.15) | 0.783 | 0.97 (0.79-1.19) | | Dominant model | 0.498 | 0.91 (0.69-1.20) | 0.535 | 0.91 (0.68-1.22) | | rs13361189 | | | | | | Allele model | 0.932 | 0.99 (0.82-1.20) | 0.823 | 1.02 (0.83-1.26) | | Dominant model | 0.852 | 1.03 (0.77-1.36) | 0.774 | 1.04 (0.78-1.40) |
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AITD, autoimmune thyroid disease; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; OR, odds ratio; 95% CI, 95% confidence intervals.
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