Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases

Table 4

Association between SNPs of IRGM gene and AITD, GD, and HT by logistic regression analysis.

Disease	Model	Unadjusted	Unadjusted OR (95% CI)	Adjusted	Adjusted; OR (95% CI)
AITD	rs10065172
	Allele model	0.097	1.13 (0.98-1.30)	0.145	1.11 (0.96-0.98)
	Dominant model	0.067	1.22 (0.99-1.51)	0.108	1.19 (0.96-1.48)
	rs4958847
	Allele model	0.063	0.87 (0.75-1.01)	0.204	0.91 (0.78-1.05)
	Dominant model	0.066	0.83 (0.68-1.01)	0.169	0.86 (0.70-1.06)
	rs13361189
	Allele model	0.121	1.12 (0.97-1.29)	0.179	1.10 (0.96-1.28)
	Dominant model	0.076	1.21 (0.98-1.50)	0.122	1.19 (0.96-1.47)
GD	rs10065172
	Allele model	0.021	1.21 (1.03-1.42)	0.033	1.20 (1.02-1.41)
	Dominant model	0.018	1.34 (1.05-1.72)	0.024	1.33 (1.04-1.70)
	rs4958847
	Allele model	0.027	0.83 (0.70-0.98)	0.084	0.86 (0.73-1.02)
	Dominant model	0.036	0.78 (0.62-0.98)	0.104	0.82 (0.65-1.04)
	rs13361189
	Allele model	0.026	1.20 (1.02-1.41)	0.042	1.19 (1.01-1.40)
	Dominant model	0.018	1.34 (1.05-1.72)	0.026	1.33 (1.03-1.70)
HT	rs10065172
	Allele model	0.990	1.00 (0.83-1.22)	0.763	1.03 (0.84-1.27)
	Dominant model	0.771	1.04 (0.79-1.38)	0.709	1.06 (0.79-1.42)
	rs4958847
	Allele model	0.585	0.95 (0.78-1.15)	0.783	0.97 (0.79-1.19)
	Dominant model	0.498	0.91 (0.69-1.20)	0.535	0.91 (0.68-1.22)
	rs13361189
	Allele model	0.932	0.99 (0.82-1.20)	0.823	1.02 (0.83-1.26)
	Dominant model	0.852	1.03 (0.77-1.36)	0.774	1.04 (0.78-1.40)

AITD, autoimmune thyroid disease; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; OR, odds ratio; 95% CI, 95% confidence intervals.