Melatonin Modulation of Sirtuin-1 Attenuates Liver Injury in a Hypercholesterolemic Mouse Model

Figure 1

Photomicrographs of liver haematoxylin-eosin staining of untreated ApoE^−/− of 6 w (a), untreated ApoE^−/− of 15 w (b), control (c), and ApoE^−/− + MEL (d). Bar: 20 μm. v: central vein, the arrowhead indicates lipid droplet deposition, the arrow identifies the inflammatory cells infiltration, and the circle indicates hepatocyte nuclear polyploidy. The graph (e) summarized the morphometrical analysis of hepatocyte nuclear area. versus ApoE^−/− of 15 w.

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