Low Performance of a Clinical-Genetic Model in the Estimation of Time in Therapeutic Range in Acenocoumarol-Adherent Patients with Nonvalvular Atrial Fibrillation: The Quality of Anticoagulation Challenge

Table 3

Unadjusted logistic regression model: predictors of time in therapeutic range <70%.

	Odds Ratio	95 CI	p-value
Clinical variables
Age, years	1.02	0.99 - 1.05	0.285
Male gender, n ()	1.03	0.60 - 1.79	0.911
Body mass index, kg/m^2	0.93	0.88 - 0.99	0.015
Current smoking, n ()	1.17	0.47 - 2.92	0.741
Dyslipidaemia, n ()	0.83	0.48 - 1.44	0.504
Hypertension, n ()	0.62	0.32 - 1.20	0.158
Type 2 diabetes mellitus, n ()	0.69	0.38 - 1.25	0.216
Previous heart failure, n ()	1.94	0.91 - 4.15	0.085
Previous stroke, n ()	1.60	0.59 - 4.33	0.359
Previous ischemic heart disease, n ()	1.07	0.55 - 2.09	0.833
Previous peripheral arterial disease, n ()	1.49	0.50 - 4.44	0.479
Previous pulmonary disease, n ()	1.27	0.66 - 2.45	0.469
Previous renal disease, n ()	1.36	0.58 - 3.20	0.476
Previous hepatic disease, n ()	-	-	-
Previous neoplasm, n ()	0.62	0.26 - 1.51	0.296
Charlson score	1.07	0.88 - 1.30	0.504
Alcohol intake, grams per day	1.00	0.96 - 1.04	0.952
Regular vitamin K intake	0.52	0.28 - 0.95	0.032
Persistent or permanent atrial fibrillation, n ()	1.74	0.99 - 3.05	0.055
SAMe-TT2R2 score	0.91	0.68 - 1.21	0.504
Age < 60 years, n ()	0.55	0.19 - 1.58	0.266
Medical history, n ()	0.94	0.52 – 1.71	0.844
Treatment (interacting medications), n ()	1.00	0.54 - 1.85	0.995
Non-Caucasian race, n ()	-	-	-
Number of active medications	1.09	0.99 - 1.20	0.090
≥ 7 active medications ()	1.41	0.81 - 2.46	0.219
Estimated glomerular filtration rate, ml/min/1.73m^2	1.00	0.99 - 1.01	0.487
Genetic variables
VKORC ≥ 1 allele T (n=212)	1.16	0.65 - 2.06	0.621
CYP2C92 ≥ 1 allele T (n=212)	0.90	0.50 - 1.59	0.706
CYP2C93 ≥ 1 allele C (n=212)	0.85	0.41 - 1.78	0.669
MIR133A2 ≥ 1 allele A (n=212)	1.13	0.64 - 2.00	0.667

CI, confidence interval. Medical history: hypertension, diabetes mellitus, ischemic heart disease, peripheral arterial disease, heart failure, previous stroke, pulmonary disease, and liver or renal disease. Number of active medications: number of tablets taken per day apart from VKA. 7 corresponds to the median value of number of active medications.