Low Performance of a Clinical-Genetic Model in the Estimation of Time in Therapeutic Range in Acenocoumarol-Adherent Patients with Nonvalvular Atrial Fibrillation: The Quality of Anticoagulation Challenge

Table 4

Multivariate logistic regression model for the prediction of time in therapeutic range <70%.

	Odds Ratio	95 CI	P value
Clinical variables
Body mass index, kg/m^2	0.94	0.89 - 0.99	0.032
Regular vitamin K intake	0.53	0.28 - 0.99	0.046
Genetic variables
VKORC ≥ 1 allele T (n=212)	1.18	0.65 - 2.16	0.591
CYP2C92 ≥ 1 allele T (n=212)	1.10	0.59 - 2.02	0.772
CYP2C93 ≥ 1 allele C (n=212)	0.80	0.37 - 1.72	0.568
MIR133A2 ≥ 1 allele A (n=212)	1.11	0.61 - 2.03	0.724

Adjusted by previous heart failure and number of active medications. Hosmer-Lemeshow: , p= 0.529.