Research Article
The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells
Table 1
The enriched pathways of DEGs between cells with Aβ1–42 alone and cells with Aβ1–42 + CUR.
| | DEGs | Terms | Name | Counts | Gene | P value |
| | Upregulated DEGs | GO: | Negative regulation of molecular function | 7 | ATP7A,
MYC… | | | GO: | Epidermis development | 6 | ATP7A,
GRPC5D… | | | GO: | Metal ion transport | 12 | ATP7A,
MCOLN1… | | | GO: | Keratinocyte differentiation | 4 | GPRC5D,
EVPL… | | | GO: | Regulation of endopeptidase activity | 4 | CDH1,
MYC… | | | GO: | Regulation of caspase activity | 4 | CDH1,
MYC… | | | GO: | Ectoderm development | 6 | ATP7A,
GPRC5D… | | | GO: | Cation transport | 13 | ATP7A,
MCOLN1… | | | GO: | Epidermal cell differentiation | 4 | GPRC5D,
EVPL… | | | GO: | Regulation of peptidase activity | 4 | CDH1,
MYC… | |
| | Downregulated DEGs | GO: | Intracellular organelle lumen | 40 | SURF6,
UTP18… | | | GO: | Membrane-enclosed lumen | 41 | HNRNPA2B1,
SIRT4… | | | GO: | Organelle lumen | 40 | SURF6,
UTP18… | | | GO: | Nuclear lumen | 31 | SURF6,
UTP18… | | | GO: | Nucleolus | 15 | TSEN54,
TBL3… | | | GO: | Nuclear pore | 6 | CSE1L,
KPNA6… | | | GO: | Mitochondrion | 39 | PGS1,
PDP2… | | | GO: | Pore complex | 6 | SIRT4,
ACACA… | | | GO: | Cilium | 8 | TTC30B,
TTC30A1… | | | GO: | Adherens junction | 7 | FMN1,
ARHGAP31… | |
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