Potential of Gene and Cell Therapy for Inner Ear Hair Cells

Table 1

Animal studies using gene therapies for genetic hearing loss model.

Year	Country	Vector	Gene	Animal	Reference
2012	US	AAV	VGLUT3	mouse; (premature)	Akil et al.
2014	US	AAV	Gjb2	mouse; (mature)	Yu et al.
2015	Japan	AAV	Gjb2	mouse; (mature and premature)	Iizuka et al.
2015	US	AAV	TMC1	mouse; (premature)	Askew et al.
2016	South Korea	AAV	MsrB3	mouse; (in utero)	Kim et al.
2017	US	AAV	USH3	mouse; (premature)	Geng et al.
2017	US	AAV	USH1C	Mouse; (premature)	Pan et al.

AAV: adenoassociated virus; VGLUT3: vesicular glutamate transporter 3; MsrB3: methionine sulfoxide reductase B3; TMC1: transmembrane channel like 1; USH3: Usher syndrome type III; USH1C: Usher syndrome type Ic.