Potential of Gene and Cell Therapy for Inner Ear Hair Cells

Table 2

Animal studies using gene therapies for hearing loss protection (or hearing preservation).

Year	Country	Vector	Ototoxic insults	Gene	Animal	Reference
1999	US	Adv	Aminoglycoside	GDNF	Guinea pig	Yagi et al.
2004	US	Adv	Aminoglycoside	SOD1	Guinea pig	Kawamoto et al.
2006	US	AAV	Cisplatin	XIAP	rat	Cooper et al.
2008	Japan/China	AAV	Aminoglycoside	GDNF	rat	Liu et al.
2008	US	siRNA	Cisplatin	TRPV1 and NOx3	rat	Mukherjea et al.
2009	US	AAV	Aminoglycoside	Bcl2	mouse; (mature)	Pfannenstiel et al.
2010	Australia	Adv	Aminoglycoside	(NT3 and BDNF)	Guinea pig	Wise et al.
2015	US	Adv	Aminoglycoside	Hsp70	Guinea pig	Takada et al.
2016	China	AAV	Cisplatin	XIAP	mouse; (mature)	Jie et al.
2016	US	siRNA	Acoustic overexposure	AMPK	Mouse; (mature)	Hill et al.

Adv: adenovirus; AAV: adenoassociated virus; GDNF: glial cell derived neurotrophic factor; SOD: superoxide dismutase; XIAP: X-linked inhibitor of apoptosis; TRPV1: Transient Receptor Potential Cation Channel Subfamily V Member 1; NOx3: NADPH Oxidase 3; NT3: neurotrophin 3; BDNF: brain derived neurotrophic factor; Hsp70: heat shock protein 70; AMPK: AMP-activated protein kinase.