Combination Use of BMP2 and VEGF165 Promotes Osseointegration and Stability of Titanium Implants in Irradiated Bone

Figure 5

(a) Fluorochrome labeling images showing osseointegration under fluorescence microscopy. Red color was labeled by alizarin red at week 1, green color was labeled by calcein green at week 2, (A) control at 2 weeks; (B) HBP at 2 weeks; (C) BMP2 at 2 weeks; (D) VEGF165 at 2 weeks; (E) BMP2/VEGF165 at 2 weeks; (F) control at 8 weeks; (G) HBP at 8 weeks; (H) BMP2 at 8 weeks; (I) VEGF165 at 8 weeks; (J) BMP2/VEGF165 at 8 weeks; (b) rate of bone growth measured by fluorochrome labeling analysis. P < 0.05. All values are expressed as mean ± SD, N=5.

(a)

(b)