Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus

Table 2

Genotype frequency distribution in diabetes cases and controls.

Variable	Diabetes, N (%)	Control, N (%)		P	OR	95% CI	OR	95% CI
rs2989924
AA	83 (23.4)	116 (30.9)	7.55	0.02	1.00		1.00
AG	207 (58.3)	182 (48.5)			1.59	1.13-2.25	1.32	0.89-1.95
GG	65 (18.3)	77 (20.5)			1.18	0.76-1.82	1.12	0.87-1.43
AA	83 (23.4)	116 (30.9)	5.25	0.022	1.00		1.00
AG+GG	272 (76.6)	259 (69.1)			1.47	1.06-2.04	1.66	1.07-2.57
AA+AG	290 (81.7)	298 (79.5)	0.58	0.45	1.00		1.00
GG	65 (18.3)	77 (20.5)			0.87	0.60-1.25	0.87	0.55-1.36
rs3758269
CC	291 (73.3)	270 (68.5)	2.19	0.34	1.00		1.00
CT	96 (24.2)	112 (28.4)			0.79	0.58-1.09	0.62	0.43-0.90
TT	10 (2.5)	12 (3.1)			0.77	0.33-1.82	0.88	0.52-1.49
CC	291 (73.3)	270 (68.5)	2.18	0.14	1.00		1.00
CT+TT	106 (26.7)	124 (31.5)			0.79	0.58-1.08	0.55	0.35-0.85
CC+CT	387 (97.5)	382 (97.0)	0.20	0.65	1.00		1.00
TT	10 (2.5)	12 (3.0)			0.82	0.35-1.93	1.25	0.40-3.93
rs62542743
CC	378 (95.7)	363 (92.8)	3.96	0.14	1.00		1.00
CA	17 (4.3)	27 (6.9)			0.61	0.32-1.13	0.70	0.35-1.41
AA	0 (0.0)	1 (0.3)			0.997	0.99-1.00	-	-
CC	378 (95.7)	363 (92.8)	2.97	0.09	1.00		1.00
CA+AA	17 (4.3)	28 (7.2)			0.58	0.31-1.08	0.88	0.41-1.89
CC+CA	395 (100.0)	390 (99.5)	1.40	0.24	1.00		1.00
AA	0 (0.00)	2 (0.5)			0.99	0.99-1.01	-	-
rs57139208
CC	299 (75.3)	292 (74.5)	0.59	0.75	1.00		1.00
CT	91 (22.9)	90 (23.0)			0.99	0.71-1.38	0.83	0.56-1.23
TT	7 (1.8)	10 (2.5)			0.68	0.26-1.82	0.77	0.44-1.35
CC	299 (75.3)	292 (74.5)	0.07	0.79	1.00		1.00
CT+TT	98 (24.7)	100 (25.5)			0.96	0.69-1.32	0.83	0.54-1.27
CC+CT	390 (98.2)	382 (97.4)	0.58	0.45	1.00		1.00
TT	7 (1.8)	10 (2.6)			0.69	0.26-1.82	0.56	0.15-2.03
rs16939881
GG	345 (86.9)	331 (87.1)	1.53	0.47	1.00		1.00
GC	45 (11.4)	46 (12.1)			0.94	0.61-1.45	0.99	0.60-1.65
CC	7 (1.8)	3 (0.8)			2.24	0.57-8.73	1.65	0.76-3.55
GG	345 (86.9)	331 (87.1)	0.01	0.93	1.00		1.00
GC+CC	52 (13.1)	49 (12.9)			1.02	0.67-1.55	1.06	0.62-1.84
GG+GC	390 (98.2)	377 (99.2)	1.45	0.23	1.00		1.00
CC	7 (1.8)	3 (0.8)			2.26	0.58-8.79	2.50	0.37-17.02

OR, odds ratio; CI, confidence interval.
Adjusted for age, gender, systolic blood pressure, fasting glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol.