Research Article
Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus
Table 2
Genotype frequency distribution in diabetes cases and controls.
| Variable | Diabetes, N (%) | Control, N (%) | | P | OR | 95% CI | OR | 95% CI |
| rs2989924 | | | | | | | | | AA | 83 (23.4) | 116 (30.9) | 7.55 | 0.02 | 1.00 | | 1.00 | | AG | 207 (58.3) | 182 (48.5) | | | 1.59 | 1.13-2.25 | 1.32 | 0.89-1.95 | GG | 65 (18.3) | 77 (20.5) | | | 1.18 | 0.76-1.82 | 1.12 | 0.87-1.43 | AA | 83 (23.4) | 116 (30.9) | 5.25 | 0.022 | 1.00 | | 1.00 | | AG+GG | 272 (76.6) | 259 (69.1) | | | 1.47 | 1.06-2.04 | 1.66 | 1.07-2.57 | AA+AG | 290 (81.7) | 298 (79.5) | 0.58 | 0.45 | 1.00 | | 1.00 | | GG | 65 (18.3) | 77 (20.5) | | | 0.87 | 0.60-1.25 | 0.87 | 0.55-1.36 | rs3758269 | | | | | | | | | CC | 291 (73.3) | 270 (68.5) | 2.19 | 0.34 | 1.00 | | 1.00 | | CT | 96 (24.2) | 112 (28.4) | | | 0.79 | 0.58-1.09 | 0.62 | 0.43-0.90 | TT | 10 (2.5) | 12 (3.1) | | | 0.77 | 0.33-1.82 | 0.88 | 0.52-1.49 | CC | 291 (73.3) | 270 (68.5) | 2.18 | 0.14 | 1.00 | | 1.00 | | CT+TT | 106 (26.7) | 124 (31.5) | | | 0.79 | 0.58-1.08 | 0.55 | 0.35-0.85 | CC+CT | 387 (97.5) | 382 (97.0) | 0.20 | 0.65 | 1.00 | | 1.00 | | TT | 10 (2.5) | 12 (3.0) | | | 0.82 | 0.35-1.93 | 1.25 | 0.40-3.93 | rs62542743 | | | | | | | | | CC | 378 (95.7) | 363 (92.8) | 3.96 | 0.14 | 1.00 | | 1.00 | | CA | 17 (4.3) | 27 (6.9) | | | 0.61 | 0.32-1.13 | 0.70 | 0.35-1.41 | AA | 0 (0.0) | 1 (0.3) | | | 0.997 | 0.99-1.00 | - | - | CC | 378 (95.7) | 363 (92.8) | 2.97 | 0.09 | 1.00 | | 1.00 | | CA+AA | 17 (4.3) | 28 (7.2) | | | 0.58 | 0.31-1.08 | 0.88 | 0.41-1.89 | CC+CA | 395 (100.0) | 390 (99.5) | 1.40 | 0.24 | 1.00 | | 1.00 | | AA | 0 (0.00) | 2 (0.5) | | | 0.99 | 0.99-1.01 | - | - | rs57139208 | | | | | | | | | CC | 299 (75.3) | 292 (74.5) | 0.59 | 0.75 | 1.00 | | 1.00 | | CT | 91 (22.9) | 90 (23.0) | | | 0.99 | 0.71-1.38 | 0.83 | 0.56-1.23 | TT | 7 (1.8) | 10 (2.5) | | | 0.68 | 0.26-1.82 | 0.77 | 0.44-1.35 | CC | 299 (75.3) | 292 (74.5) | 0.07 | 0.79 | 1.00 | | 1.00 | | CT+TT | 98 (24.7) | 100 (25.5) | | | 0.96 | 0.69-1.32 | 0.83 | 0.54-1.27 | CC+CT | 390 (98.2) | 382 (97.4) | 0.58 | 0.45 | 1.00 | | 1.00 | | TT | 7 (1.8) | 10 (2.6) | | | 0.69 | 0.26-1.82 | 0.56 | 0.15-2.03 | rs16939881 | | | | | | | | | GG | 345 (86.9) | 331 (87.1) | 1.53 | 0.47 | 1.00 | | 1.00 | | GC | 45 (11.4) | 46 (12.1) | | | 0.94 | 0.61-1.45 | 0.99 | 0.60-1.65 | CC | 7 (1.8) | 3 (0.8) | | | 2.24 | 0.57-8.73 | 1.65 | 0.76-3.55 | GG | 345 (86.9) | 331 (87.1) | 0.01 | 0.93 | 1.00 | | 1.00 | | GC+CC | 52 (13.1) | 49 (12.9) | | | 1.02 | 0.67-1.55 | 1.06 | 0.62-1.84 | GG+GC | 390 (98.2) | 377 (99.2) | 1.45 | 0.23 | 1.00 | | 1.00 | | CC | 7 (1.8) | 3 (0.8) | | | 2.26 | 0.58-8.79 | 2.50 | 0.37-17.02 |
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OR, odds ratio; CI, confidence interval. Adjusted for age, gender, systolic blood pressure, fasting glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol. |