Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus
Table 3
Stratified analysis between SNPs and type 2 diabetes.
Additive model
OR (95 CI)
Recessive model
OR (95 CI)
Dominant model
OR (95 CI)
Diabetes
Controls
Diabetes
Controls
Diabetes
Controls
DD ()
Dd ()
dd ()
DD ()
Dd ()
dd ()
DD+Dd ()
dd ()
DD+Dd ()
dd ()
DD ()
Dd+dd ()
DD ()
Dd+dd ()
rs2989924
Age ≤ 50 (years)
12 (18.5)
38 (58.5)
15 (23.1)
23 (28.0)
41 (50.0)
18 (22.0)
1.46 (0.86-2.47)
50 (76.9)
15 (23.1)
64 (78.0)
18 (22.0)
1.12 (0.46-2.73)
12 (18.5)
53 (81.5)
23 (28.0)
59 (72.0)
1.91 (0.77-4.76)
Age > 50 (years)
71 (24.5)
169 (58.3)
50 (17.2)
93 (31.7)
141 (48.1)
59 (20.1)
1.67 (1.02-2.72)
240 (82.8)
50 (17.2)
234 (79.9)
59 (20.1)
0.83 (0.54-1.25)
71 (24.5)
219 (75.5)
93 (31.7)
200 (68.3)
1.67 (1.02-2.72)
Females
47 (26.3)
106 (59.2)
26 (14.5)
57 (31.0)
95 (51.6)
32 (17.4)
0.98 (0.67-1.42)
153 (85.5)
26 (14.5)
152 (82.6)
32 (17.4)
0.73 (0.36-1.51)
47 (26.3)
132 (73.7)
57 (31.0)
127 (69.0)
1.19 (0.67-2.12)
Males
36 (20.5)
101 (57.4)
39 (22.2)
59 (30.9)
87 (45.5)
45 (23.6)
1.21 (0.87-1.02)
137 (77.8)
39 (22.2)
146 (76.4)
45 (23.6)
0.94 (0.53-1.66)
36 (20.5)
140 (79.5)
59 (30.9)
132 (69.1)
1.54 (0.88-2.70)
Normal weight
35 (24.3)
75 (52.1)
34 (23.6)
48 (33.1)
72 (49.7)
25 (17.2)
1.40 (0.96-2.04)
110 (76.4)
34 (23.6)
120 (82.8)
25 (17.2)
1.76 (0.92-3.39)
35 (24.3)
109 (75.7)
48 (33.1)
97 (66.9)
1.41 (0.79-2.52)
Overweight
48 (22.7)
132 (62.6)
31 (14.7)
68 (29.6)
110 (47.8)
52 (22.6)
1.16 (0.85-1.59)
180 (85.3)
31 (14.7)
178 (77.4)
52 (22.6)
1.49 (0.98-2.25)
48 (22.7)
163 (77.3)
68 (29.6)
162 (70.4)
1.88 (1.02-3.44)
Without central obesity
28 (25.0)
61 (54.5)
23 (21.2)
31 (29.8)
51 (49.0)
22 (21.2)
1.01 (0.65-1.58)
89 (79.5)
23 (20.5)
82 (78.8)
22 (21.2)
1.08 (0.50-2.35)
28 (25.0)
84 (75.0)
31 (29.8)
73 (70.2)
0.95 (0.46-1.99)
With central obesity
55 (22.7)
146 (60.3)
41 (16.9)
84 (31.7)
126 (47.5)
55 (20.8)
1.30 (0.98-1.72)
201 (83.1)
41 (16.9)
210 (79.2)
55 (20.8)
0.78 (0.49-1.22)
55 (22.7)
187 (77.3)
84 (31.7)
181 (68.3)
1.92 (1.11-3.34)
rs3758269
Age ≤ 50 (years)
57 (74.0)
16 (20.8)
4 (5.2)
63 (70.8)
26 (29.2)
0 (0.0)
0.93 (0.48-1.81)
73 (94.8)
4 (5.2)
89 (100.0)
0 (0.0)
-
57 (74.0)
20 (26.0)
63 (70.8)
26 (29.2)
0.62 (0.28-1.35)
Age > 50 (years)
234 (73.1)
80 (25.0)
6 (1.9)
207 (67.9)
86 (28.2)
12 (3.9)
0.56 (0.36-0.86)
314 (98.1)
6 (1.9)
293 (96.1)
12 (3.9)
0.47 (0.17-1.26)
234 (73.1)
86 (26.9)
207 (67.9)
98 (32.1)
0.50 (0.30-0.84)
Females
146 (76.4)
41 (21.5)
4 (2.1)
134 (71.3)
50 (26.6)
4 (2.1)
0.44 (0.24-0.81)
187 (97.9)
4 (2.1)
184 (97.9)
4 (2.1)
0.98 (0.24-3.99)
146 (76.4)
45 (23.6)
134 (71.3)
54 (28.7)
0.28 (0.13-0.59)
Males
145 (70.4)
55 (26.7)
6 (2.9)
136 (66.0)
62 (30.1)
8 (3.9)
0.79 (0.53-1.19)
200 (97.1)
6 (2.9)
198 (96.1)
8 (3.9)
0.71 (0.89-2.67)
145 (70.4)
61 (29.6)
136 (66.0)
70 (34.0)
0.81 (0.49-1.31)
Normal weight
117 (72.7)
40 (24.8)
4 (2.5)
111 (70.7)
43 (27.4)
3 (1.9)
0.83 (0.48-1.45)
157 (97.5)
4 (2.5)
154 (98.1)
3 (1.9)
1.21 (0.21-7.08)
117 (72.7)
44 (27.3)
111 (70.7)
46 (29.3)
0.75 (0.42-1.34)
Overweight
174 (73.7)
56 (23.7)
6 (2.5)
159 (67.1)
69 (29.1)
9 (3.8)
0.59 (0.35-0.99)
230 (97.5)
6 (2.5)
228 (96.2)
9 (3.8)
0.66 (0.23-1.88)
174 (73.7)
62 (26.3)
159 (67.1)
78 (32.9)
0.49 (0.27-0.89)
Without central obesity
95 (76.0)
27 (21.6)
3 (2.4)
77 (69.4)
31 (27.9)
3 (2.7)
0.62 (0.35-1.10)
122 (97.6)
3 (2.4)
108 (97.3)
3 (2.7)
1.26 (0.19-8.13)
95 (76.0)
30 (24.0)
77 (69.4)
34 (30.6)
0.53 (0.26-1.06)
With central obesity
195 (72.2)
68 (25.2)
7 (2.6)
188 (67.9)
80 (28.9)
9 (3.2)
0.65 (0.44-0.98)
263 (97.4)
7 (2.6)
268 (96.8)
9 (3.2)
1.10 (0.26-4.63)
195 (72.2)
75 (27.8)
188 (67.9)
89 (32.1)
0.60 (0.38-0.95)
OR, odds ratio; CI, confidence interval; D, wild-type allele; d, risk allele; BMI, body mass index. Adjusted for age, gender, systolic blood pressure, fasting glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol, where appropriate.
