p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

Figure 1

Potential contributions of p300/CBP to development of hepatic lipid metabolism. Red arrow: hepatic de novo lipogenesis and hyperlipidemia in p300/CBP regulation: the scheme indicates the regulatory actions of the inducible p300/CBP acetylation and their effects on de novo lipogenesis in both enzymatic and transcriptional events. Blue arrow: the regulation of p300/CBP in lipid export by interacting with DDX3 and inducing acetylation of HNF4 which increased the MTP promoter activation (HNF4: hepatocyte nuclear factor 4; MTP: microsomal triglyceride transfer protein).