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BioMed Research International
Volume 2018, Article ID 8182575, 7 pages
Research Article

Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity

1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
2Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
3Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
4Department of Oncology, Second Affiliated Hospital of Anhui Medical University, Anhui 230000, China
5Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Correspondence should be addressed to Shengping Li; nc.gro.ccusys@phsil

Received 3 July 2017; Accepted 29 January 2018; Published 22 February 2018

Academic Editor: Michel Kahaleh

Copyright © 2018 Zeyu Shuang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alpha-L-fucosidase (AFU) has been reported to be a predictor of survival in patients with several cancers, but it is unclear whether AFU is associated with prognosis in patients with intrahepatic cholangiocarcinoma (iCCA). In this study, we used receiver operating characteristic (ROC) analysis to generate the cutoff point of AFU for overall survival (OS). The prognostic influence of the AFU level in serum on OS was studied using Kaplan-Meier curves. Moreover, invasion assays and Western blotting were performed to explore the effects of AFU on iCCA invasion in vitro. We found that higher AFU levels (≥20.85 U/L) were significantly associated with favorable median OS (44.3 months versus 20.1 months; ) in iCCA patients. Cox regression models’ analyses showed that the AFU level was an independent predictor for OS (). Moreover, our results revealed that the AFU could impair the invasion capability of the iCCA cells, HuH28, and also downregulated the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. In conclusion, our results indicate that AFU is a significantly favorable prognostic factor in iCCA patients.