Research Article
Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity
Table 2
Univariate and multivariate analyses of factors affecting overall survival in patients with intrahepatic cholangiocarcinoma (iCCA).
| Characteristics | Univariate | Multivariate | Hazard ratio (95% CI) | value | Hazard ratio (95% CI) | value |
| Age (years) | | | | <60 | 1 (reference) | 0.925 | n.d. | n.d. | ≥60 | 0.978 (0.614–1.558) | Gender | | | | Female | 1 (reference) | 0.119 | n.d. | n.d. | Male | 1.464 (0.907–2.363) | Lymph node metastasis | | | | No | 1 (reference) | <0.001 | 1 (reference) | 0.001 | Yes | 2.746 (1.744–4.323) | 2.407 (1.435–4.037) | Tumor number | | | | Solitary | 1 (reference) | 0.006 | | NS | Multiple | 1.856 (1.191–2.893) | Tumor size (cm) | | | | ≤5 | 1 (reference) | 0.001 | | NS | >5 | 2.210 (1.364–3.581) | TNM stage | | | | I | 1 (reference) | <0.001 | 1 (reference) | 0.002 | II–IV | 3.542 (1.983–6.328) | 2.677 (1.418–5.053) | AFU (U/L) | | | | <20.85 | 1 (reference) | 0.023 | 1 (reference) | 0.006 | ≥20.85 | 0.596 (0.381–0.932) | 0.526 (0.331–0.834) | CA19-9 (U/mL) | | | | <100 | 1 (reference) | <0.001 | 1 (reference) | <0.001 | ≥100 | 2.793 (1.786–4.368) | 2.778 (1.748–4.412) | ALT (U/L) | | | | ≤40 | 1 (reference) | 0.664 | n.d. | n.d. | >40 | 1.117 (0.678–1.839) | AST (U/L) | | | | ≤45 | 1 (reference) | 0.210 | n.d. | n.d. | >45 | 0.608 (0.280–1.323) |
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CI: confidence interval; AST: aspartate transaminase; ALT: alanine aminotransferase; AFU: alpha-L-fucosidase; CA19-9: carbohydrate antigen 19-9; n.d.: not done; NS: no significance.
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