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BioMed Research International
Volume 2018 (2018), Article ID 8207058, 14 pages
Review Article

The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?

1Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
2Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
3Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China

Correspondence should be addressed to Ling Yang; nc.anis@gnilgnayzc and Chun Yang; moc.anis@ztnuhcgnay

Received 30 November 2017; Revised 19 January 2018; Accepted 7 February 2018; Published 18 March 2018

Academic Editor: Rei Shibata

Copyright © 2018 Ye-Shun Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular disease remains the leading cause of morbidity and mortality, imposing a major disease burden worldwide. Therefore, there is an urgent need to identify new therapeutic targets. Recently, the concept that the heart acts as a secretory organ has attracted increasing attention. Proteins secreted by the heart are called cardiokines, and they play a critical physiological role in maintaining heart homeostasis or responding to myocardial damage and thereby influence the development of heart diseases. Given the critical role of cardiokines in heart disease, they might represent a promising therapeutic target. This review will focus on several cardiokines and discuss their roles in the pathogenesis of heart diseases and as potential therapeutics.