Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way

Table 2

Polymorphism rs755622 C allele upregulates DDT expression in brain and blood for MS patients.

Transcript ID	Gene	SNP	Effect allele	P value	Effect size (β)	Tissues	GEO dataset
ENST00000428792.1	DDT	rs755622	C	2.23E-308	6.72E+03	Brain optic chiasm	GSE100297
ENST00000428792.1	DDT	rs755622	C	2.91E-15	3.60E+01	Blood	GSE66573
ENST00000444947.2	DDT	rs755622	C	1.62E-02	1.23E+05	Blood	GSE66573

The rs755622 position (hg19), 22_24236392_G_C_b37 (G > C); the threshold of significant association is 0.05; and means that this effect allele upregulates and downregulates gene expression, respectively.