Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way

Table 3

Regulation of rs755622 polymorphism to DDT expression level in different gender.

Gender	Gene	SNP	Effect allele	P value	Effect size (β)	Tissues	Sample size
Female+Male	DDT	rs755622	C	2.80E-02	1.29E-01	Brain hippocampus	122
Female	DDT	rs755622	C	1.05E-01	1.96E-01	Brain hippocampus	30
Male	DDT	rs755622	C	4.41E-02	1.40E-01	Brain hippocampus	92
Female+Male	DDT	rs755622	C	2.26E-02	1.24E-01	Brain intralobular white matter	131
Female	DDT	rs755622	C	3.14E-01	1.28E-01	Brain intralobular white matter	34
Male	DDT	rs755622	C	2.03E-02	1.46E-01	Brain intralobular white matter	97

Significant associations () marked in bold. The rs755622 position (hg19), 22_24236392_G_C_b37 (G > C); the threshold of significant association is 0.05; and means that this effect allele up-regulates and down-regulates gene expression, respectively.