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BioMed Research International
Volume 2018 (2018), Article ID 8286067, 8 pages
https://doi.org/10.1155/2018/8286067
Clinical Study

Serum Soluble Vascular Cell Adhesion Molecule-1 Overexpression Is a Disease Marker in Patients with First-Time Diagnosed Antinuclear Antibodies: A Prospective, Observational Pilot Study

1Praxis für Rheumatologie, Köln, Germany
2Medizinische Klinik III, Hematology, Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany
3Schmerzklinik Basel, Basel, Switzerland

Correspondence should be addressed to Matthias F. Seidel

Received 1 October 2017; Revised 22 December 2017; Accepted 3 January 2018; Published 1 February 2018

Academic Editor: Gernot Zissel

Copyright © 2018 Mara Oleszowsky and Matthias F. Seidel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Giannouli, D. Chatzidimitriou, S. Gerou, E. Gavriilaki, L. Settas, and E. Diza, “Frequency and specificity of antibodies against nuclear and cytoplasmic antigens in healthy individuals by classic and new methods,” Clinical Rheumatology, vol. 32, no. 10, pp. 1541–1546, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. J. V. Peter, M. F. Griffith, J. A. J. Prakash, A. Chrispal, K. Pichamuthu, and G. M. Varghese, “Anti-nuclear antibody expression in severe scrub typhus infection: preliminary observations,” Journal of Global Infectious Diseases, vol. 6, no. 4, pp. 195-196, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. M. O’Sullivan, A. McLean-Tooke, and R. Loh, “Antinuclear antibody test,” Australian Family Physician, vol. 42, no. 10, pp. 718–721, 2013. View at Google Scholar · View at Scopus
  4. M. Koenig, M. Dieudé, and J.-L. Senécal, “Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies,” Autoimmunity Reviews, vol. 7, no. 8, pp. 588–593, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. K. T. Ho and J. D. Reveille, “The clinical relevance of autoantibodies in scleroderma,” Arthritis Research & Therapy, vol. 5, no. 2, pp. 80–93, 2003. View at Google Scholar · View at Scopus
  6. A. Sulli, B. Ruaro, V. Smith et al., “Progression of nailfold microvascular damage and antinuclear antibody pattern in systemic sclerosis,” The Journal of Rheumatology, vol. 40, no. 5, pp. 634–639, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. A. E. Koch and O. Distler, “Vasculopathy and disordered angiogenesis in selected rheumatic diseases: Rheumatoid arthritis and systemic sclerosis,” Arthritis Research & Therapy, vol. 9, supplement 2, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. W. McMurray, “Adhesion molecules in autoimmune disease,” Seminars in Arthritis and Rheumatism, vol. 25, no. 4, pp. 215–233, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Seron, J. S. Cameron, and D. O. Haskard, “Expression of VCAM-1 in the normal and diseased kidney,” Nephrology Dialysis Transplantation , vol. 6, no. 12, pp. 917–922, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. E. A. Clark, K. H. Grabstein, and G. L. Shu, “Cultured human follicular dendritic cells: Growth characteristics and interactions with B lymphocytes,” The Journal of Immunology, vol. 148, no. 11, pp. 3327–3335, 1992. View at Google Scholar · View at Scopus
  11. L. S. Wilkinson, J. C. W. Edwards, R. N. Poston, and D. O. Haskard, “Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium,” Laboratory Investigation, vol. 68, no. 1, pp. 82–88, 1993. View at Google Scholar · View at Scopus
  12. B. W. Needleman, “Increased expression of intercellular adhesion molecule 1 on the fibroblasts of scleroderma patients,” Arthritis & Rheumatism, vol. 33, no. 12, pp. 1847–1851, 1990. View at Publisher · View at Google Scholar · View at Scopus
  13. M. P. Bevilacqua, S. Stengelin, M. A. Gimbrone Jr., and B. Seed, “Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins,” Science, vol. 243, no. 4895, pp. 1160–1165, 1989. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Sugama, “Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion,” The Journal of Cell Biology, vol. 119, no. 4, pp. 935–944, 1992. View at Publisher · View at Google Scholar
  15. O. Distler, A. Del Rosso, and R. Giacomelli, “Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers,” Arthritis Research & Therapy, vol. 4, article R11, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Coll-Vinent, C. Vilardell, C. Font et al., “Circulating soluble adhesion molecules in patients with giant cell arteritis. Correlation between soluble intercellular adhesion molecule-1 (sICAM-1) concentrations and disease activity,” Annals of the Rheumatic Diseases, vol. 58, no. 3, pp. 189–192, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Yamane, H. Ihn, M. Kubo et al., “Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma,” Journal of the American Academy of Dermatology, vol. 42, no. 1 I, pp. 64–69, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Kaplanski, P. Cacoub, C. Farnarier et al., “Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis,” Arthritis & Rheumatology, vol. 43, no. 1, pp. 55–64, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Bečvář, J. Štork, V. Pešáková et al., “Clinical correlations of potential activity markers in systemic sclerosis,” Annals of the New York Academy of Sciences, vol. 1051, pp. 404–412, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. R. E. Navarro-Hernández, E. Oregon-Romero, M. V.-D. Mercado, H. Rangel-Villalobos, C. A. Palafox-Sánchez, and J. F. Muoz-Valle, “Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity. Association with genetic polymorphisms,” Disease Markers, vol. 26, no. 3, pp. 119–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. A. D. Blann, A. Herrick, and M. I. V. Jayson, “Altered levels of soluble adhesion molecules in rheumatoid arthritis, vasculitis and systemic sclerosis,” Rheumatology, vol. 34, no. 9, pp. 814–819, 1995. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Ihn, S. Sato, M. Fujimoto, K. Takehara, and K. Tamaki, “Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis,” British Journal of Rheumatology, vol. 37, no. 11, pp. 1188–1192, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. M. S. Gruschwitz, O. P. Hornstein, and P. V. D. Driesch, “Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity,” Arthritis & Rheumatism, vol. 38, no. 2, pp. 184–189, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Kahaleh, “Vascular disease in scleroderma: mechanisms of vascular injury,” Rheumatic Disease Clinics of North America, vol. 34, no. 1, pp. 57–71, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Muangchan, S. Harding, S. Khimdas, A. Bonner, M. Baron, and J. Pope, “Association of C-reactive protein with high disease activity in systemic sclerosis: results from the Canadian Scleroderma Research Group,” Arthritis Care & Research, vol. 64, no. 9, pp. 1405–1414, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Valentini, S. D'Angelo, A. Della Rossa, W. Bencivelli, and S. Bombardieri, “European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. IV. Assessment of skin thickening by modified Rodnan skin score,” Annals of the Rheumatic Diseases, vol. 62, no. 9, pp. 904-905, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Aletaha, T. Neogi, and A. J. Silman, “Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative,” Arthritis & Rheumatism, vol. 62, no. 9, pp. 2569–2581, 2010. View at Google Scholar
  28. F. Van den Hoogen, D. Khanna, J. Fransen et al., “classification criteria for systemic sclerosis: an American College of Rheumatology/European league against Rheumatism collaborative initiative,” Arthritis & Rheumatology, vol. 65, no. 11, pp. 2737–2747, 2013. View at Google Scholar
  29. M. C. Hochberg, “Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus,” Arthritis & Rheumatology, vol. 40, no. 9, article 1725, 1997. View at Google Scholar · View at Scopus
  30. C. Vitali, S. Bombardieri, R. Jonsson et al., “Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European consensus group,” Annals of the Rheumatic Diseases, vol. 61, no. 6, pp. 554–558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Mosca, R. Neri, and S. Bombardieri, “Undifferentiated connective tissue diseases (UCTD): A review of the literature and a proposal for preliminary classification criteria,” Clinical and Experimental Rheumatology, vol. 17, no. 5, pp. 615–620, 1999. View at Google Scholar · View at Scopus
  32. E. R. Volkmann, M. Taylor, and A. Ben-Artzi, “Using the antinuclear antibody test to diagnose rheumatic diseases: when does a positive test warrant further investigation?” Southern Medical Journal, vol. 105, no. 2, pp. 100–104, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Walravens, “Systemic diseases and the detection of antinuclear and anticytoplasmic antibodies. An hystorical review,” Clinical Rheumatology, vol. 6, no. 1, pp. 9–17, 1987. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Kubo, H. Ihn, K. Yamane et al., “Increased serum levels of soluble vascular cell adhesion molecule-1 and soluble E-selectin in patients with polymyositis/dermatomyositis,” British Journal of Dermatology, vol. 143, no. 2, pp. 392–398, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. P. E. Spronk, H. Bootsma, M. G. Huitema, P. C. Limburg, and C. G. M. Kallenberg, “Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE); a long term prospective study,” Clinical & Experimental Immunology, vol. 97, no. 3, pp. 439–444, 1994. View at Google Scholar · View at Scopus
  36. M. Cuida, A.-K. Halse, A. C. Johannessen, T. Tynning, and R. Jonsson, “Indicators of salivary gland inflammation in primary Sjögren’s syndrome,” European Journal of Oral Sciences, vol. 105, no. 3, pp. 228–233, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. A. L. Herrick, K. Illingworth, A. Blann, C. R. M. Hay, S. Hollis, and M. I. V. Jayson, “Von Willebrand factor, thrombomodulin, thromboxane, β-thromboglobulin and markers of fibrinolysis in primary Raynaud’s phenomenon and systemic sclerosis,” Annals of the Rheumatic Diseases, vol. 55, no. 2, pp. 122–127, 1996. View at Publisher · View at Google Scholar · View at Scopus
  38. M. M. Cerinic, G. Valentini, G. G. Sorano et al., “Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis,” Seminars in Arthritis and Rheumatism, vol. 32, no. 5, pp. 285–295, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Kuryliszyn-Moskal, P. A. Klimiuk, and S. Sierakowski, “Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement,” Clinical Rheumatology, vol. 24, no. 2, pp. 111–116, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. C. A. Davies, M. Jeziorska, A. J. Freemont, and A. L. Herrick, “The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis,” Human Pathology, vol. 37, no. 2, pp. 190–197, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. L. K. Hummers, “Microvascular damage in systemic sclerosis: detection and monitoring with biomarkers,” Current Rheumatology Reports, vol. 8, no. 2, pp. 131–137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. S. V. Castro and S. A. Jimenez, “Biomarkers in systemic sclerosis,” Biomarkers in Medicine, vol. 4, no. 1, pp. 133–147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. C. P. Denton, M. C. M. Bickerstaff, X. Shiwen et al., “Serial circulating adhesion molecule levels reflect disease severity in systemic sclerosis,” Rheumatology, vol. 34, no. 11, pp. 1048–1054, 1995. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Kiener, W. Graninger, K. Machold, M. Aringer, and W. B. Graninger, “Increased levels of circulating intercellular adhesion molecule-1 in patients with systemic sclerosis,” Clinical and Experimental Rheumatology, vol. 12, no. 5, pp. 483–487, 1994. View at Google Scholar · View at Scopus
  45. K. P. Machold, H. P. Kiener, W. Graninger, and W. B. Graninger, “Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with rheumatoid arthritis and systemic lupus erythematosus,” Clinical Immunology and Immunopathology, vol. 68, no. 1, pp. 74–78, 1993. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Pope, K. M. Walker, F. de Leon, L. Vanderhoek, S. Seney, and K. L. Summers, “Correlations between changes in cytokines and clinical outcomes for early phase (proof of concept) trials in active diffuse systemic sclerosis using data from an imatinib study,” Rheumatology, vol. 53, no. 10, pp. 1830–1834, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. P. Rehberger, P. Beckheinrich-Mrowka, U.-F. Haustein, and M. Sticherling, “Prostacyclin analogue iloprost influences endothelial cell-associated soluble adhesion molecules and growth factors in patients with systemic sclerosis: a time course study of serum concentrations,” Acta Dermato-Venereologica, vol. 89, no. 3, pp. 245–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. Y. Allanore, D. Borderie, H. Lemaréchal, O. G. Ekindjian, and A. Kahan, “Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1,” Arthritis Research & Therapy, vol. 6, no. 4, pp. R309–R314, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Oleszowsky and M. Seidel, “Soluble vascular cell adhesion molecule-1 is overexpressed as a disease marker in patients with first-time diagnosed antinuclear antibodies and significantly decreases after immunosuppression in patients with systemic sclerosis, annals of the rheumatic Diseases,” Annals of The Rheumatic Diseases, vol. 74, article 601, 2015, FRI0478. View at Google Scholar