Association between Participants’ Characteristics, Patient-Reported Outcomes, and Clinical Outcomes in Youth with Sickle Cell Disease

Table 3

PROMIS® quality of life domains intercorrelations.

PROMIS® Domains	Depression	Anxiety	PF-Mobility	PF-UE	Pain interference
Fatigue	0.68 (p<0.0001)	0.54 (p=0.002)	-0.63 (p<0.001)	-0.39 (p=0.03)	0.69 (p<0.0001)
Pain interference	0.63 (p<0.001)	0.58 (p<0.001)	-0.40 (p=0.03)	-0.44 (p=0.01)
PF-UE	-0.60 (p<0.001)	-0.47 (p=0.01)	0.62 (p<0.001)
PF-Mobility	-0.55 (p=0.002)	-0.36 (p=0.04)
Anxiety	0.83 (p<0.0001)

P-value < 0.05 was statistically significant.
All PROMIS® data were reported as T-scores.
PF: physical function; PROMIS: patient reported outcomes measurement information system; UE: upper extremity.
Higher PROMIS® scores indicated more severe or worse fatigue, pain interference, depression, or anxiety, while lower PROMIS® scores indicated more limited, impaired or worse upper extremity physical function, or mobility physical function.