Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 3
Genetic model analyses of IL-16-rs859, CYP24A1-rs4809957, and FBN1-rs1042078with lung cancer risk.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 384) | (N = 322) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 706) | rs859
(call rate 99.86%) | Codominant | A/A | 92 (24.0%) | 89 (27.7%) | 1.00 | 0.200 | 1.00 | 0.058 | | G/A | 190 (49.5%) | 164 (51.1%) | 0.89 (0.62-1.28) | 0.82 (0.55-1.22) | | G/G | 102 (26.6%) | 68 (21.2%) | 0.69 (0.45-1.05) | 0.57 (0.36-0.91) | | Dominant | A/A | 92 (24.0%) | 89 (27.7%) | 1.00 | 0.250 | 1.00 | 0.100 | | G/A-G/G | 292 (76.0%) | 232 (72.3%) | 0.82 (0.59-1.15) | 0.73 (0.50-1.06) | | Recessive | A/A-G/A | 282 (73.4%) | 253 (78.8%) | 1.00 | 0.095 | 1.00 | 0.029 | | G/G | 102 (26.6%) | 68 (21.2%) | 0.74 (0.52-1.06) | 0.65 (0.44-0.96) | | Log-additive | --- | --- | --- | 0.83 (0.67-1.03) | 0.086 | 0.76 (0.60-0.96) | 0.019 |
| CYP24A1
(N = 706) | rs4809957
(call rate 100%) | Codominant | G/G | 143 (37.2%) | 124 (38.5%) | 1.00 | 0.940 | 1.00 | 0.560 | | G/A | 185 (48.2%) | 152 (47.2%) | 0.95 (0.69-1.31) | 0.89 (0.62-1.27) | | A/A | 56 (14.6%) | 46 (14.3%) | 0.95 (0.60-1.50) | 0.76 (0.46-1.27) | | Dominant | G/G | 143 (37.2%) | 124 (38.5%) | 1.00 | 0.730 | 1.00 | 0.370 | | G/A-A/A | 241 (62.8%) | 198 (61.5%) | 0.95 (0.70-1.29) | 0.86 (0.61-1.20) | | Recessive | G/G-G/A | 328 (85.4%) | 276 (85.7%) | 1.00 | 0.910 | 1.00 | 0.400 | | A/A | 56 (14.6%) | 46 (14.3%) | 0.98 (0.64-1.49) | 0.82 (0.51-1.31) | | Log-additive | --- | --- | --- | 0.97 (0.78-1.20) | 0.760 | 0.88 (0.69-1.12) | 0.280 |
| FBN1
(N = 706) | rs1042078
(call rate 100%) | Codominant | A/A | 117 (30.5%) | 85 (26.4%) | 1.00 | 0.065 | 1.00 | 0.200 | | A/G | 185 (48.2%) | 183 (56.8%) | 1.36 (0.96-1.92) | 1.27 (0.86-1.86) | | G/G | 82 (21.4%) | 54 (16.8%) | 0.91 (0.58-1.41) | 0.88 (0.54-1.44) | | Dominant | A/A | 117 (30.5%) | 85 (26.4%) | 1.00 | 0.230 | 1.00 | 0.450 | | A/G-G/G | 267 (69.5%) | 237 (73.6%) | 1.22 (0.88-1.70) | 1.15 (0.80-1.66) | | Recessive | A/A-A/G | 302 (78.7%) | 268 (83.2%) | 1.00 | 0.120 | 1.00 | 0.190 | | G/G | 82 (21.4%) | 54 (16.8%) | 0.74 (0.51-1.09) | 0.76 (0.50-1.15) | | Log-additive | --- | --- | --- | 0.99 (0.80-1.23) | 0.920 | 0.97 (0.76-1.23) | 0.790 |
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SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, gender, smoking status, and alcohol drinking status. Bold italics indicates the statistical significance ( P < 0.05). |
