Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 4
The relationship between IL-16-rs859, CYP24A1-rs4809957,and FBN1-rs1042078 and lung cancer risk among the people aged older than 50.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 228) | (N = 264) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 492) | rs859
(call rate 100%) | Codominant | A/A | 44 (19.3%) | 72 (27.3%) | 1.00 | 0.009 | 1.00 | 0.021 | | G/A | 109 (47.8%) | 135 (51.1%) | 0.76 (0.48-1.19) | 0.79 (0.49-1.29) | | G/G | 75 (32.9%) | 57 (21.6%) | 0.46 (0.28-0.77) | 0.48 (0.28-0.83) | | Dominant | A/A | 44 (19.3%) | 72 (27.3%) | 1.00 | 0.037 | 1.00 | 0.079 | | G/A-G/G | 184 (80.7%) | 192 (72.7%) | 0.64 (0.42-0.98) | 0.66 (0.42-1.05) | | Recessive | A/A-G/A | 153 (67.1%) | 207 (78.4%) | 1.00 | 0.0048 | 1.00 | 0.0089 | | G/G | 75 (32.9%) | 57 (21.6%) | 0.56 (0.38-0.84) | 0.56 (0.36-0.87) | | Log-additive | --- | --- | --- | 0.68 (0.53-0.87) | 0.0026 | 0.69 (0.52-0.91) | 0.0071 |
| CYP24A1
(N = 492) | rs4809957
(call rate 100%) | Codominant | G/G | 84 (36.8%) | 97 (36.7%) | 1.00 | 1.000 | 1.00 | 0.780 | | G/A | 111 (48.7%) | 128 (48.5%) | 1.00 (0.68-1.47) | 0.98 (0.64-1.48) | | A/A | 33 (14.5%) | 39 (14.8%) | 1.02 (0.59-1.77) | 0.81 (0.44-1.48) | | Dominant | G/G | 84 (36.8%) | 97 (36.7%) | 1.00 | 0.980 | 1.00 | 0.750 | | G/A-A/A | 144 (63.2%) | 167 (63.3%) | 1.00 (0.70-1.45) | 0.94 (0.63-1.40) | | Recessive | G/G-G/A | 195 (85.5%) | 225 (85.2%) | 1.00 | 0.930 | 1.00 | 0.490 | | A/A | 33 (14.5%) | 39 (14.8%) | 1.02 (0.62-1.69) | 0.82 (0.47-1.43) | | Log-additive | --- | --- | --- | 1.01 (0.78-1.31) | 0.950 | 0.92 (0.69-1.22) | 0.560 |
| FBN1
(N = 492) | rs1042078
(call rate 100%) | Codominant | A/A | 69 (30.3%) | 72 (27.3%) | 1.00 | 0.250 | 1.00 | 0.380 | | A/G | 114 (50.0%) | 151 (57.2%) | 1.27 (0.84-1.91) | 1.18 (0.75-1.84) | | G/G | 45 (19.7%) | 41 (15.5%) | 0.87 (0.51-1.49) | 0.82 (0.46-1.46) | | Dominant | A/A | 69 (30.3%) | 72 (27.3%) | 1.00 | 0.460 | 1.00 | 0.740 | | A/G-G/G | 159 (69.7%) | 192 (72.7%) | 1.16 (0.78-1.71) | 1.08 (0.70-1.65) | | Recessive | A/A-A/G | 183 (80.3%) | 223 (84.5%) | 1.00 | 0.220 | 1.00 | 0.230 | | G/G | 45 (19.7%) | 41 (15.5%) | 0.75 (0.47-1.19) | 0.74 (0.45-1.22) | | Log-additive | --- | --- | --- | 0.97 (0.75-1.27) | 0.840 | 0.94 (0.70-1.25) | 0.650 |
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SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, gender, smoking status, and alcohol drinking status. Bold italics indicates the statistical significance ( P < 0.05). |
