Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 6
The relationship between IL-16-rs859, CYP24A1-rs4809957,and FBN1-rs1042078 and lung adenocarcinoma risk.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 384) | (N = 150) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 534) | rs859
(call rate 100%) | Codominant | A/A | 92 (24.0%) | 39 (26.0%) | 1.00 | 0.150 | 1.00 | 0.035 | | G/A | 190 (49.5%) | 83 (55.3%) | 1.03 (0.65-1.62) | 0.90 (0.55-1.48) | | G/G | 102 (26.6%) | 28 (18.7%) | 0.65 (0.37-1.14) | 0.49 (0.27-0.90) | | Dominant | A/A | 92 (24.0%) | 39 (26.0%) | 1.00 | 0.620 | 1.00 | 0.240 | | G/A-G/G | 292 (76.0%) | 111 (74.0%) | 0.90 (0.58-1.38) | 0.75 (0.47-1.21) | | Recessive | A/A-G/A | 282 (73.4%) | 122 (81.3%) | 1.00 | 0.052 | 1.00 | 0.010 | | G/G | 102 (26.6%) | 28 (18.7%) | 0.63 (0.40-1.01) | 0.53 (0.32-0.87) | | Log-additive | --- | --- | --- | 0.82 (0.62-1.07) | 0.140 | 0.71 (0.53-0.95) | 0.022 |
| CYP24A1
(N = 534) | rs4809957
(call rate 100%) | Codominant | G/G | 143 (37.2%) | 64 (42.7%) | 1.00 | 0.270 | 1.00 | 0.210 | | G/A | 185 (48.2%) | 71 (47.3%) | 0.86 (0.57-1.28) | 0.81 (0.53-1.25) | | A/A | 56 (14.6%) | 15 (10.0%) | 0.60 (0.32-1.14) | 0.55 (0.28-1.09) | | Dominant | G/G | 143 (37.2%) | 64 (42.7%) | 1.00 | 0.250 | 1.00 | 0.180 | | G/A-A/A | 241 (62.8%) | 86 (57.3%) | 0.80 (0.54-1.17) | 0.75 (0.50-1.14) | | Recessive | G/G-G/A | 328 (85.4%) | 135 (90.0%) | 1.00 | 0.150 | 1.00 | 0.130 | | A/A | 56 (14.6%) | 15 (10.0%) | 0.65 (0.36-1.19) | 0.62 (0.32-1.17) | | Log-additive | --- | --- | --- | 0.80 (0.60-1.06) | 0.120 | 0.77 (0.56-1.04) | 0.083 |
| FBN1
(N = 534) | rs1042078
(call rate 100%) | Codominant | A/A | 117 (30.5%) | 39 (26.0%) | 1.00 | 0.110 | 1.00 | 0.150 | | A/G | 185 (48.2%) | 87 (58.0%) | 1.41 (0.91-2.20) | 1.28 (0.80-2.05) | | G/G | 82 (21.4%) | 24 (16.0%) | 0.88 (0.49-1.57) | 0.76 (0.41-1.41) | | Dominant | A/A | 117 (30.5%) | 39 (26.0%) | 1.00 | 0.300 | 1.00 | 0.630 | | A/G-G/G | 267 (69.5%) | 111 (74.0%) | 1.25 (0.82-1.91) | 1.12 (0.71-1.76) | | Recessive | A/A-A/G | 302 (78.7%) | 126 (84.0%) | 1.00 | 0.160 | 1.00 | 0.099 | | G/G | 82 (21.4%) | 24 (16.0%) | 0.70 (0.43-1.16) | 0.65 (0.38-1.10) | | Log-additive | --- | --- | --- | 0.98 (0.75-1.29) | 0.890 | 0.91 (0.68-1.22) | 0.530 |
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SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, gender, smoking status, and alcohol drinking status. Bold italics indicates the statistical significance ( P < 0.05). |
